NFL Defensive interceptions leaders — DEF, wins, 2000–2026

The defensive players with the most defensive interceptions since 2000, in wins.

Player	POS	Team	GP	DEF INT
#1Ed Reed	FS		99	52
#2Darren Sharper	FS		99	46
#3Asante Samuel	CB		108	43
#4Charles Woodson	FS		116	42
#5Champ Bailey	CB		103	33
#6Terence Newman	CB		132	31
#7Deltha O'Neal	CB		76	30
#7Richard Sherman	CB		91	30
#9Charles Tillman	CB		97	29
#9Devin McCourty	FS	NE	146	29
#11Harrison Smith	FS	MIN	124	28
#12Dominique Rodgers-Cromartie	CB		71	27
#12Kevin Byard	FS		91	27
#12Ronde Barber	FS	TB	100	27
#12Troy Polamalu	S	PIT	101	27
#16Brent Grimes	CB		72	26
#16Darrelle Revis	DB		73	26
#16Dre' Bly	CB		66	26
#16Patrick Surtain	CB		65	26
#16Sammy Knight	DB		76	26
#16Tyrann Mathieu	FS		108	26
#22Antonio Cromartie	CB		95	25
#22Reggie Nelson	FS		93	25
#24DeAngelo Hall	S		65	24
#24Marcus Peters	CB		79	24
#24Patrick Peterson	CB		106	24
#24Stephon Gilmore	CB		97	24
#24Ty Law	CB		65	24
#29Anthony Henry	CB		62	23
#29Aqib Talib	CB		80	23
#29Earl Thomas	FS		91	23
#29Tory James	CB		66	23
#33Greg Wesley	FS	KC	60	22
#33Tramon Williams	CB		117	22
#35Eric Weddle	FS		111	21
#35Rashean Mathis	CB		85	21
#35Ray Lewis	ILB	BAL	105	21
#35Samari Rolle	CB		68	21
#39Antrel Rolle	S		76	20
#39Chris Harris	CB		101	20
#39Darius Slay	CB		103	20
#39Duron Harmon	S		106	20
#39J.C. Jackson	DB		43	20
#39Kerby Joseph	SAF	DET	38	20
#39Kurt Coleman	S		88	20
#39Micah Hyde	S		98	20
#39Michael Griffin	FS		68	20
#39Mike Adams	FS		107	20
#39Nate Clements	S		74	20
#39Sam Madison	CB		70	20
#51Antoine Bethea	FS		108	19
#51Brian Dawkins	S		98	19
#51Casey Hayward	CB		84	19
#51Johnathan Joseph	CB		104	19
#51Leon Hall	DB		77	19
#51Sheldon Brown	CB		91	19
#51Tashaun Gipson	FS		81	19
#51Walt Harris	CB		68	19
#51Xavien Howard	CB		55	19
#60C.J. Gardner-Johnson	SAF		69	18
#60Chris Gamble	CB	CAR	59	18
#60Chris McAlister	DB		68	18
#60Deon Grant	S		86	18
#60Dexter McCleon	DB		56	18
#60Jessie Bates	FS		58	18
#60Justin Simmons	FS		54	18
#60Marcus Trufant	CB	SEA	72	18
#60Marlon Humphrey	CB	BAL	91	18
#60Tony Parrish	S		42	18
#60Trumaine Johnson	CB		42	18
#71Aaron Glenn	DB		53	17
#71Brandon Carr	CB		102	17
#71Brent Alexander	FS		53	17
#71Glover Quin	FS		86	17
#71Kareem Jackson	S		92	17
#71Malcolm Jenkins	S		122	17
#71Mike McKenzie	CB		66	17
#71Rasul Douglas	CB		76	17
#71Sam Shields	CB		70	17
#71Tre'Davious White	CB		70	17
#81Adrian Wilson	S	ARI	71	16
#81Brian Williams	DB		68	16
#81Chris Harris	DB		62	16
#81Chris Hope	S		92	16
#81Dwight Smith	S		47	16
#81Jairus Byrd	DB		48	16
#81Jordan Poyer	FS		95	16
#81Keith Bulluck	OLB		95	16
#81Ken Lucas	CB		74	16
#81Logan Ryan	CB		93	16
#81Reshad Jones	FS	MIA	51	16
#81Tim Jennings	CB		77	16
#81Trevon Diggs	CB		36	16
#94Brian Urlacher	MLB	CHI	101	15
#94Brock Marion	FS		45	15
#94Byron Murphy	CB		60	15
#94Corey Webster	CB	NYG	69	15
#94Dashon Goldson	DB		56	15
#94Deshea Townsend	DB		102	15
#94Donnie Abraham	CB		39	15