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The defensive linemen with the most defensive interceptions in the 2025 season.
| Player | POS | Team | GP | DEF INT | SCK | PD | SOLO | AST | TOT TKL | TFL | QBH | FF | FUM REC | SCKY |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1Laiatu Latu | DE |  IND | 16 | 3 | 8.5 | 5 | 25 | 18 | 43 | 12 | 20 | 1 | ||
| #2Aidan Hutchinson | DE |  DET | 17 | 1 | 14.5 | 3 | 35 | 18 | 53 | 14 | 35 | 4 | ||
| #2Ashton Gillotte | DE |  KC | 16 | 1 | 1.5 | 1 | 14 | 24 | 38 | 3 | 8 | 0 | ||
| #2Carl Granderson | DE |  NO | 16 | 1 | 6 | 4 | 32 | 22 | 54 | 11 | 9 | 0 | ||
| #2Charles Snowden | DE |  LV | 12 | 1 | 3 | 2 | 16 | 11 | 27 | 5 | 4 | 0 | ||
| #2Da'Shawn Hand | DE |  LAC | 13 | 1 | 1.5 | 4 | 16 | 11 | 27 | 5 | 5 | 0 | ||
| #2DaQuan Jones | DT |  BUF | 12 | 1 | 3 | 2 | 10 | 11 | 21 | 3 | 8 | 1 | ||
| #2Dexter Lawrence | DT |  NYG | 16 | 1 | 0.5 | 4 | 13 | 17 | 30 | 4 | 8 | 0 | ||
| #2Grover Stewart | DT | IND | 17 | 1 | 0.5 | 4 | 21 | 32 | 53 | 5 | 7 | 1 | ||
| #2Kobie Turner | DE |  LAR | 17 | 1 | 7 | 3 | 23 | 24 | 47 | 9 | 14 | 0 | ||
| #2Maxx Crosby | DE | LV | 15 | 1 | 10 | 6 | 42 | 28 | 70 | 28 | 20 | 2 | ||
| #2Quinnen Williams | DT | 15 | 1 | 2.5 | 1 | 25 | 27 | 52 | 10 | 12 | 3 |
| 0 |
| 41 |
| 0 |
| 104.5 |
| 0 |
| 2 |
| 0 |
| 25 |
| 0 |
| 15 |
| 1 |
| 5 |
| 0 |
| 8 |
| 0 |
| 3.5 |
| 0 |
| 0 |
| 0 |
| 61 |
| 0 |
| 50 |
| 15.5 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Buffalo Bills | 3–1 | .750 | +20 |
 New England Patriots | 2–2 | .500 | -12 |
 New York Jets | 1–3 | .250 | -8 |
 Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Baltimore Ravens | 3–1 | .750 | +20 |
 Cleveland Browns | 3–1 | .750 | -14 |
 Cincinnati Bengals | 2–2 | .500 | +12 |
 Pittsburgh Steelers | 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Jacksonville Jaguars | 3–1 | .750 | +51 |
| Indianapolis Colts | 2–2 | .500 | -2 |
 Houston Texans | 0–4 | .000 | -25 |
 Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Kansas City Chiefs | 4–0 | 1.000 | +41 |
| Las Vegas Raiders | 3–1 | .750 | +31 |
 Denver Broncos | 2–2 | .500 | -20 |
| Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| New York Giants | 3–1 | .750 | +3 |
 Dallas Cowboys | 2–2 | .500 | +10 |
 Philadelphia Eagles | 2–2 | .500 | -18 |
 Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Minnesota Vikings | 4–0 | 1.000 | +35 |
 Chicago Bears | 3–1 | .750 | +47 |
| Detroit Lions | 2–2 | .500 | -8 |
 Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Carolina Panthers | 2–2 | .500 | +12 |
 Atlanta Falcons | 2–2 | .500 | +4 |
| New Orleans Saints | 1–3 | .250 | -23 |
 Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 San Francisco 49ers | 4–0 | 1.000 | +58 |
 Seattle Seahawks | 3–1 | .750 | +32 |
| Los Angeles Rams | 2–2 | .500 | +2 |
 Arizona Cardinals | 1–3 | .250 | -30 |
