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The safeties with the most defensive interceptions in the 2025 season.
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| #2Antonio Johnson | SAF |  JAX | 16 | 5 | 2 | 9 | 37 | 21 | 58 | 2 | 1 | 0 | 0 | 1 | 8 |
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| #2Xavier Watts | SAF |  ATL | 17 | 5 | 0 | 11 | 57 | 37 | 94 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #4Calen Bullock | SAF |  HOU | 16 | 4 | 0 | 10 | 43 | 20 | 63 | 0 | 0 | 1 | 0 | 0 | 0 |
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| #4Camryn Bynum | SAF |  IND | 17 | 4 | 1 | 8 | 47 | 31 | 78 | 3 | 0 | 1 | 0 | 0 | 15 |
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| #4Jalen Pitre | SAF | HOU | 14 | 4 | 0 | 12 | 41 | 31 | 72 | 3 | 0 | 0 | 0 | 0 | 0 |
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| #4Jaylinn Hawkins | SAF |  NE | 15 | 4 | 1.5 | 6 | 44 | 26 | 70 | 3 | 5 | 1 | 0 | 0 | 9 |
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| #4Jordan Battle | SAF |  CIN | 17 | 4 | 0 | 6 | 60 | 63 | 123 | 2 | 0 | 2 | 0 | 0 | 0 |
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| #4Tony Jefferson | S |  LAC | 12 | 4 | 0 | 7 | 36 | 20 | 56 | 1 | 2 | 0 | 0 | 0 | 0 |
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| #10Cole Bishop | SAF |  BUF | 16 | 3 | 2 | 7 | 52 | 32 | 84 | 4 | 2 | 0 | 0 | 0 | 10 |
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| #10Derwin James | FS | LAC | 15 | 3 | 2 | 7 | 49 | 44 | 93 | 6 | 8 | 1 | 0 | 0 | 13.5 |
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| #10Evan Williams | SAF |  GB | 16 | 3 | 0 | 5 | 46 | 52 | 98 | 4 | 0 | 0 | 0 | 0 | 0 |
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| #10Jessie Bates | FS | ATL | 17 | 3 | 0 | 6 | 56 | 41 | 97 | 1 | 2 | 1 | 0 | 1 | 0 |
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| #10Kerby Joseph | SAF |  DET | 6 | 3 | 0 | 4 | 14 | 4 | 18 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #15Andrew Mukuba | SAF |  PHI | 11 | 2 | 0.5 | 3 | 24 | 19 | 43 | 2 | 1 | 0 | 0 | 0 | 5.5 |
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| #15Antoine Winfield Jr. | SAF |  TB | 17 | 2 | 1 | 8 | 53 | 40 | 93 | 4 | 4 | 1 | 0 | 0 | 8 |
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| #15C.J. Gardner-Johnson | SAF | 13 | 2 | 3 | 4 | 45 | 20 | 65 | 5 | 6 | 1 | 0 | 0 | 24 |
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| #15Dadrion Taylor-Demerson | SAF |  ARI | 12 | 2 | 0 | 6 | 31 | 27 | 58 | 0 | 0 | 0 | 1 | 0 | 0 |
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| #15Donovan Wilson | SAF |  DAL | 15 | 2 | 0 | 5 | 39 | 32 | 71 | 3 | 0 | 1 | 0 | 0 | 0 |
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| #15Geno Stone | SAF | CIN | 16 | 2 | 2 | 4 | 64 | 39 | 103 | 4 | 4 | 0 | 0 | 1 | 11 |
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| #15Harrison Smith | FS |  MIN | 14 | 2 | 1 | 10 | 37 | 17 | 54 | 3 | 2 | 1 | 0 | 0 | 7 |
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| #15Isaiah Pola-Mao | SAF |  LV | 17 | 2 | 0 | 4 | 57 | 34 | 91 | 4 | 0 | 0 | 0 | 0 | 0 |
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| #15Ji'Ayir Brown | SAF |  SF | 16 | 2 | 0 | 6 | 43 | 32 | 75 | 2 | 0 | 1 | 0 | 0 | 0 |
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| #15Jonas Sanker | SAF |  NO | 16 | 2 | 0 | 6 | 45 | 34 | 79 | 3 | 0 | 0 | 0 | 0 | 0 |
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| #15Josh Metellus | SAF | MIN | 14 | 2 | 0.5 | 6 | 40 | 44 | 84 | 1 | 2 | 0 | 0 | 0 | 0 |
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| #15Kam Curl | SAF |  LAR | 17 | 2 | 2 | 5 | 75 | 43 | 118 | 2 | 2 | 1 | 0 | 0 | 2 |
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| #15Kamren Kinchens | SAF | LAR | 17 | 2 | 0 | 6 | 54 | 28 | 82 | 0 | 2 | 0 | 0 | 0 | 0 |
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| #15Kyle Dugger | SAF | 16 | 2 | 1 | 5 | 29 | 30 | 59 | 2 | 1 | 0 | 0 | 1 | 5 |
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| #15Malaki Starks | SAF |  BAL | 17 | 2 | 0 | 4 | 48 | 35 | 83 | 1 | 1 | 0 | 0 | 0 | 0 |
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| #15R.J. Mickens | SAF | LAC | 10 | 2 | 0 | 2 | 18 | 11 | 29 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #15Ronnie Hickman Jr. | SAF |  CLE | 17 | 2 | 0 | 7 | 51 | 52 | 103 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #15Xavier McKinney | SAF | GB | 16 | 2 | 1 | 10 | 52 | 53 | 105 | 0 | 2 | 1 | 0 | 0 | 0 |
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| #15Xavier Woods | FS |  TEN | 10 | 2 | 1 | 3 | 23 | 16 | 39 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #34Andrew Wingard | SAF | JAX | 16 | 1 | 0 | 9 | 43 | 39 | 82 | 3 | 1 | 0 | 0 | 0 | 0 |
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| #34Ashtyn Davis | SAF |  MIA | 13 | 1 | 0 | 4 | 41 | 22 | 63 | 3 | 0 | 1 | 0 | 0 | 0 |
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| #34Avonte Maddox | FS | DET | 8 | 1 | 0 | 4 | 23 | 9 | 32 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #34Brandon Jones | SAF |  DEN | 14 | 1 | 0.5 | 7 | 42 | 35 | 77 | 0 | 2 | 0 | 0 | 0 | 6 |
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| #34Budda Baker | S | ARI | 16 | 1 | 0.5 | 5 | 54 | 63 | 117 | 4 | 1 | 0 | 0 | 0 | 3 |
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| #34Dane Belton | SAF |  NYG | 17 | 1 | 2 | 5 | 60 | 60 | 120 | 3 | 2 | 3 | 0 | 0 | 11 |
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| #34DeShon Elliott | SAF |  PIT | 5 | 1 | 1 | 2 | 20 | 18 | 38 | 1 | 3 | 1 | 0 | 0 | 8 |
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| #34Eric Murray | S | JAX | 12 | 1 | 1 | 6 | 30 | 22 | 52 | 2 | 2 | 1 | 0 | 0 | 11 |
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| #34Grant Delpit | SAF | CLE | 17 | 1 | 3 | 4 | 45 | 41 | 86 | 4 | 7 | 2 | 0 | 0 | 18 |
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| #34Ifeatu Melifonwu | SAF | MIA | 14 | 1 | 1 | 1 | 30 | 22 | 52 | 1 | 1 | 0 | 0 | 0 | 13 |
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| #34Jaquan Brisker | SAF |  CHI | 17 | 1 | 1 | 8 | 50 | 41 | 91 | 1 | 3 | 0 | 0 | 0 | 9 |
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| #34Jevon Holland | SAF | NYG | 13 | 1 | 0 | 5 | 38 | 25 | 63 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #34Jordan Poyer | FS | BUF | 10 | 1 | 0.5 | 3 | 31 | 39 | 70 | 1 | 1 | 0 | 0 | 0 | 4 |
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| #34Julian Love | SAF |  SEA | 7 | 1 | 1 | 6 | 22 | 11 | 33 | 1 | 1 | 0 | 0 | 0 | 12 |
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| #34Justin Reid | S | NO | 15 | 1 | 0.5 | 6 | 37 | 35 | 72 | 2 | 1 | 0 | 0 | 1 | 5.5 |
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| #34Lathan Ransom | SAF |  CAR | 15 | 1 | 1 | 2 | 21 | 30 | 51 | 2 | 1 | 1 | 0 | 0 | 8 |
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| #34Malik Mustapha | SAF | SF | 12 | 1 | 0 | 3 | 42 | 32 | 74 | 3 | 1 | 0 | 0 | 0 | 0 |
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| #34Markquese Bell | SAF | DAL | 15 | 1 | 0 | 3 | 19 | 21 | 40 | 1 | 1 | 1 | 0 | 0 | 0 |
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| #34Minkah Fitzpatrick | FS | MIA | 14 | 1 | 1 | 6 | 57 | 23 | 80 | 4 | 2 | 1 | 0 | 0 | 9 |
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| #34Nick Cross | SAF | IND | 17 | 1 | 2.5 | 5 | 70 | 48 | 118 | 5 | 6 | 1 | 0 | 0 | 11.5 |
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| #34Nick Emmanwori | SAF | SEA | 14 | 1 | 2.5 | 11 | 55 | 25 | 80 | 9 | 4 | 0 | 0 | 0 | 13 |
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| #34Nick Scott | SAF | CAR | 17 | 1 | 0 | 3 | 63 | 47 | 110 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #34Quentin Lake | SAF | LAR | 10 | 1 | 1 | 10 | 35 | 24 | 59 | 2 | 2 | 1 | 0 | 0 | 13 |
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| #34Reed Blankenship | SAF | PHI | 16 | 1 | 0 | 4 | 53 | 30 | 83 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #34Thomas Harper | SAF | DET | 10 | 1 | 0 | 5 | 26 | 11 | 37 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #34Tre'von Moehrig | SAF | CAR | 16 | 1 | 3 | 2 | 60 | 38 | 98 | 14 | 7 | 0 | 0 | 0 | 21 |
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| #34Ty Okada | SAF | SEA | 15 | 1 | 1.5 | 6 | 45 | 19 | 64 | 3 | 2 | 0 | 0 | 0 | 11.5 |
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| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Buffalo Bills | 3–1 | .750 | +20 |
| New England Patriots | 2–2 | .500 | -12 |
 New York Jets | 1–3 | .250 | -8 |
| Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Baltimore Ravens | 3–1 | .750 | +20 |
| Cleveland Browns | 3–1 | .750 | -14 |
| Cincinnati Bengals | 2–2 | .500 | +12 |
| Pittsburgh Steelers | 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Jacksonville Jaguars | 3–1 | .750 | +51 |
| Indianapolis Colts | 2–2 | .500 | -2 |
| Houston Texans | 0–4 | .000 | -25 |
| Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Kansas City Chiefs | 4–0 | 1.000 | +41 |
| Las Vegas Raiders | 3–1 | .750 | +31 |
| Denver Broncos | 2–2 | .500 | -20 |
| Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| New York Giants | 3–1 | .750 | +3 |
| Dallas Cowboys | 2–2 | .500 | +10 |
| Philadelphia Eagles | 2–2 | .500 | -18 |
 Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Minnesota Vikings | 4–0 | 1.000 | +35 |
| Chicago Bears | 3–1 | .750 | +47 |
| Detroit Lions | 2–2 | .500 | -8 |
| Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Carolina Panthers | 2–2 | .500 | +12 |
| Atlanta Falcons | 2–2 | .500 | +4 |
| New Orleans Saints | 1–3 | .250 | -23 |
| Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| San Francisco 49ers | 4–0 | 1.000 | +58 |
| Seattle Seahawks | 3–1 | .750 | +32 |
| Los Angeles Rams | 2–2 | .500 | +2 |
| Arizona Cardinals | 1–3 | .250 | -30 |
