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The NFL players with the most defensive interceptions in the 2021 season.
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| #2J.C. Jackson | DB |  NE | 17 | 8 | 0 | 23 | 40 | 14 | 54 | 1 | 0 | 1 | 0 | 1 | 0 |
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| #3Amani Oruwariye | CB |  DET | 14 | 6 | 0 | 11 | 42 | 13 | 55 | 2 | 0 | 0 | 0 | 0 | 0 |
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| #4Jordan Poyer | FS |  BUF | 16 | 5 | 3 | 9 | 58 | 27 | 85 | 7 | 3 | 0 | 0 | 0 | 26 |
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| #4Justin Simmons | FS |  DEN | 17 | 5 | 1.5 | 12 | 49 | 20 | 69 | 1 | 2 | 0 | 0 | 0 | 13 |
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| #4Kevin Byard | FS |  TEN | 17 | 5 | 1 | 13 | 42 | 31 | 73 | 1 | 4 | 2 | 0 | 1 | 11 |
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| #4Micah Hyde | S | BUF | 17 | 5 | 1 | 10 | 49 | 21 | 70 | 3 | 2 | 1 | 0 | 1 | 6 |
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| #4Quandre Diggs | S |  SEA | 17 | 5 | 0 | 7 | 54 | 28 | 82 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #4Rasul Douglas | CB |  GB | 12 | 5 | 0 | 13 | 51 | 5 | 56 | 1 | 0 | 1 | 0 | 2 | 0 |
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| #4Xavien Howard | CB |  MIA | 16 | 5 | 1 | 16 | 35 | 11 | 46 | 0 | 1 | 2 | 0 | 1 | 0 |
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| #4Xavier McKinney | SAF |  NYG | 17 | 5 | 0 | 10 | 54 | 34 | 88 | 1 | 0 | 0 | 0 | 1 | 0 |
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| #12Adrian Phillips | DB | NE | 17 | 4 | 0 | 9 | 41 | 36 | 77 | 1 | 1 | 1 | 0 | 1 | 0 |
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| #12Bobby McCain | CB |  WAS | 17 | 4 | 0 | 9 | 46 | 16 | 62 | 0 | 0 | 0 | 0 | 1 | 0 |
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| #12Byron Murphy | CB |  ARI | 16 | 4 | 0.5 | 12 | 49 | 15 | 64 | 0 | 1 | 1 | 0 | 1 | 0.5 |
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| #12Jalen Ramsey | CB |  LAR | 16 | 4 | 0 | 16 | 52 | 15 | 67 | 8 | 1 | 1 | 0 | 0 | 0 |
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| #12James Bradberry | CB | NYG | 16 | 4 | 0 | 17 | 36 | 10 | 46 | 0 | 0 | 0 | 1 | 0 | 0 |
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| #12Kenny Moore II | CB |  IND | 17 | 4 | 1 | 13 | 73 | 20 | 93 | 6 | 1 | 1 | 0 | 0 | 1 |
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| #12Kyle Dugger | SAF | NE | 15 | 4 | 0 | 5 | 56 | 22 | 78 | 3 | 2 | 0 | 0 | 0 | 0 |
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| #12Logan Wilson | LB |  CIN | 13 | 4 | 1 | 4 | 50 | 43 | 93 | 5 | 1 | 1 | 0 | 0 | 2 |
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| #12Pat Surtain II | CB | DEN | 15 | 4 | 0 | 14 | 45 | 13 | 58 | 1 | 0 | 0 | 0 | 1 | 0 |
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| #12Shaquille Leonard | OLB | IND | 16 | 4 | 0 | 8 | 58 | 47 | 105 | 4 | 3 | 8 | 1 | 0 | 0 |
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| #12Taylor Rapp | SAF | LAR | 17 | 4 | 1.5 | 6 | 51 | 30 | 81 | 2 | 3 | 0 | 0 | 0 | 7 |
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| #23A.J. Terrell | CB |  ATL | 16 | 3 | 1 | 16 | 51 | 29 | 80 | 3 | 1 | 1 | 0 | 0 | 2 |
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| #23Ahkello Witherspoon | CB |  PIT | 8 | 3 | 0 | 9 | 12 | 1 | 13 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #23Anthony Averett | CB |  BAL | 13 | 3 | 0 | 11 | 43 | 8 | 51 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #23Anthony Barr | OLB |  MIN | 11 | 3 | 2.5 | 5 | 31 | 34 | 65 | 1 | 6 | 0 | 0 | 0 | 17 |
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| #23Anthony Brown | CB |  DAL | 16 | 3 | 0 | 17 | 56 | 12 | 68 | 1 | 0 | 1 | 0 | 1 | 0 |
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| #23Budda Baker | S | ARI | 17 | 3 | 2 | 7 | 60 | 35 | 95 | 6 | 3 | 0 | 0 | 0 | 5 |
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| #23C.J. Gardner-Johnson | SAF |  NO | 12 | 3 | 2 | 7 | 31 | 14 | 45 | 4 | 4 | 0 | 0 | 0 | 14 |
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| #23Chandon Sullivan | DB | GB | 15 | 3 | 0 | 4 | 21 | 6 | 27 | 2 | 0 | 0 | 0 | 0 | 0 |
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| #23Darius Slay | CB |  PHI | 16 | 3 | 0 | 9 | 37 | 12 | 49 | 4 | 0 | 0 | 0 | 1 | 0 |
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| #23Denzel Ward | CB |  CLE | 15 | 3 | 0.5 | 10 | 33 | 9 | 42 | 1 | 2 | 0 | 0 | 1 | 2 |
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| #23Desmond King | DB |  HOU | 16 | 3 | 0 | 6 | 63 | 25 | 88 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #23Devin McCourty | FS | NE | 17 | 3 | 0 | 10 | 40 | 18 | 58 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #23Foye Oluokun | LB | ATL | 17 | 3 | 2 | 6 | 88 | 90 | 178 | 3 | 7 | 1 | 0 | 0 | 14 |
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| #23Isaiah Rodgers | CB | IND | 15 | 3 | 0 | 7 | 35 | 10 | 45 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #23Jalen Thompson | DB | ARI | 17 | 3 | 0 | 7 | 70 | 42 | 112 | 3 | 2 | 0 | 0 | 0 | 0 |
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| #23John Johnson | DB | CLE | 15 | 3 | 0.5 | 5 | 32 | 24 | 56 | 1 | 2 | 1 | 0 | 0 | 0 |
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| #23Jourdan Lewis | CB | DAL | 16 | 3 | 1.5 | 11 | 45 | 14 | 59 | 1 | 3 | 1 | 0 | 0 | 4.5 |
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| #23Lonnie Johnson | SAF | HOU | 13 | 3 | 0 | 6 | 33 | 17 | 50 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #23Marshon Lattimore | CB | NO | 16 | 3 | 0 | 19 | 53 | 13 | 66 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #23Mike Edwards | SAF |  TB | 13 | 3 | 0 | 7 | 31 | 12 | 43 | 1 | 0 | 1 | 0 | 2 | 0 |
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| #23P.J. Williams | S | NO | 15 | 3 | 2 | 5 | 35 | 6 | 41 | 2 | 4 | 1 | 0 | 1 | 16 |
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| #23Paulson Adebo | CB | NO | 16 | 3 | 0 | 8 | 51 | 11 | 62 | 4 | 0 | 0 | 0 | 0 | 0 |
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| #23Tyrann Mathieu | FS |  KC | 16 | 3 | 1 | 6 | 57 | 16 | 73 | 2 | 2 | 0 | 0 | 1 | 11 |
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| #23Xavier Woods | FS | MIN | 17 | 3 | 1 | 10 | 65 | 36 | 101 | 1 | 1 | 2 | 0 | 0 | 3 |
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| #47Adrian Amos | S | GB | 17 | 2 | 0 | 8 | 68 | 18 | 86 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Antoine Winfield Jr. | SAF | TB | 13 | 2 | 2 | 6 | 59 | 26 | 85 | 3 | 3 | 2 | 0 | 0 | 8 |
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| #47Asante Samuel Jr. | CB |  LAC | 12 | 2 | 0 | 11 | 31 | 10 | 41 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #47Ashtyn Davis | SAF |  NYJ | 13 | 2 | 0.5 | 3 | 37 | 19 | 56 | 0 | 1 | 3 | 0 | 0 | 3 |
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| #47Bashaud Breeland | CB | MIN | 13 | 2 | 0 | 5 | 38 | 16 | 54 | 1 | 0 | 2 | 0 | 0 | 0 |
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| #47Bobby Okereke | ILB | IND | 17 | 2 | 1 | 4 | 66 | 43 | 109 | 3 | 2 | 0 | 0 | 0 | 9 |
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| #47Brandin Echols | CB | NYJ | 14 | 2 | 0 | 9 | 46 | 13 | 59 | 1 | 0 | 0 | 0 | 1 | 0 |
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| #47Caden Sterns | SAF | DEN | 12 | 2 | 2 | 5 | 22 | 6 | 28 | 2 | 2 | 0 | 0 | 0 | 12 |
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| #47Cameron Sutton | CB | PIT | 14 | 2 | 0 | 6 | 43 | 8 | 51 | 4 | 0 | 1 | 0 | 0 | 0 |
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| #47Charvarius Ward | CB | KC | 13 | 2 | 0 | 10 | 44 | 19 | 63 | 2 | 0 | 0 | 0 | 0 | 0 |
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| #47Chidobe Awuzie | CB | CIN | 14 | 2 | 0 | 14 | 49 | 11 | 60 | 4 | 0 | 0 | 0 | 0 | 0 |
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| #47Chuck Clark | SAF | BAL | 16 | 2 | 1 | 12 | 45 | 31 | 76 | 2 | 1 | 0 | 0 | 1 | 12 |
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| #47Cole Holcomb | LB | WAS | 16 | 2 | 1 | 7 | 66 | 59 | 125 | 1 | 2 | 2 | 0 | 1 | 0 |
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| #47D.J. Reed | CB | SEA | 14 | 2 | 0 | 10 | 48 | 16 | 64 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Damontae Kazee | S | DAL | 17 | 2 | 0 | 4 | 33 | 17 | 50 | 0 | 0 | 2 | 0 | 0 | 0 |
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| #47Daniel Sorensen | DB | KC | 17 | 2 | 1 | 8 | 38 | 11 | 49 | 2 | 3 | 0 | 0 | 1 | 9 |
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| #47Darnell Savage | SAF | GB | 16 | 2 | 0 | 9 | 43 | 15 | 58 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #47David Long Jr. | ILB | TEN | 10 | 2 | 0 | 6 | 40 | 29 | 69 | 3 | 2 | 0 | 0 | 0 | 0 |
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| #47De'Vondre Campbell | OLB | GB | 16 | 2 | 2 | 5 | 88 | 44 | 132 | 5 | 6 | 2 | 0 | 0 | 8 |
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| #47Deon Bush | SAF |  CHI | 12 | 2 | 0 | 5 | 28 | 9 | 37 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Derwin James | FS | LAC | 15 | 2 | 2 | 5 | 70 | 43 | 113 | 6 | 7 | 3 | 0 | 0 | 12.5 |
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| #47Donte Jackson | CB |  CAR | 12 | 2 | 0 | 10 | 48 | 11 | 59 | 2 | 0 | 1 | 0 | 0 | 0 |
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| #47Duron Harmon | S | ATL | 17 | 2 | 0 | 5 | 39 | 23 | 62 | 1 | 1 | 0 | 0 | 0 | 0 |
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| #47Eli Apple | CB | CIN | 16 | 2 | 0 | 10 | 35 | 11 | 46 | 2 | 0 | 0 | 1 | 0 | 0 |
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| #47Eric Kendricks | MLB | MIN | 15 | 2 | 5 | 4 | 63 | 62 | 125 | 7 | 5 | 0 | 0 | 0 | 36 |
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| #47Ernest Jones | LB | LAR | 11 | 2 | 1 | 4 | 29 | 25 | 54 | 1 | 3 | 0 | 0 | 0 | 4 |
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| #47Greedy Williams | CB | CLE | 12 | 2 | 0 | 10 | 34 | 6 | 40 | 0 | 0 | 1 | 0 | 0 | 0 |
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| #47Jamal Adams | LB | SEA | 12 | 2 | 0 | 5 | 47 | 31 | 78 | 1 | 2 | 0 | 0 | 0 | 0 |
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| #47Jamel Dean | CB | TB | 14 | 2 | 0 | 9 | 39 | 9 | 48 | 2 | 0 | 0 | 0 | 0 | 0 |
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| #47Jaylinn Hawkins | SAF | ATL | 11 | 2 | 0 | 3 | 12 | 11 | 23 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Jayron Kearse | S | DAL | 16 | 2 | 1 | 10 | 60 | 34 | 94 | 7 | 6 | 0 | 0 | 0 | 2 |
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| #47Jevon Holland | SAF | MIA | 15 | 2 | 2.5 | 10 | 44 | 21 | 65 | 3 | 7 | 0 | 2 | 0 | 24 |
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| #47Jimmie Ward | SAF |  SF | 16 | 2 | 0 | 6 | 44 | 26 | 70 | 1 | 0 | 0 | 0 | 1 | 0 |
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| #47Jordan Whitehead | FS | TB | 14 | 2 | 0 | 8 | 52 | 15 | 67 | 5 | 1 | 1 | 0 | 0 | 0 |
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| #47Justin Coleman | CB | MIA | 12 | 2 | 0 | 3 | 19 | 7 | 26 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #47Justin Reid | S | HOU | 13 | 2 | 0 | 4 | 36 | 25 | 61 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #47Khari Willis | S | IND | 10 | 2 | 1.5 | 4 | 36 | 20 | 56 | 2 | 2 | 0 | 0 | 0 | 7.5 |
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| #47Kristian Fulton | CB | TEN | 13 | 2 | 0 | 14 | 29 | 10 | 39 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Kyzir White | OLB | LAC | 17 | 2 | 1 | 3 | 66 | 54 | 120 | 5 | 4 | 2 | 0 | 0 | 1 |
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| #47L'Jarius Sneed | CB | KC | 15 | 2 | 1 | 8 | 55 | 19 | 74 | 6 | 2 | 1 | 0 | 0 | 21 |
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| #47Landon Collins | LB | WAS | 13 | 2 | 3 | 2 | 46 | 30 | 76 | 7 | 2 | 1 | 0 | 0 | 7 |
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| #47Levi Wallace | DB | BUF | 17 | 2 | 0 | 10 | 42 | 11 | 53 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #47Malcolm Smith | MLB | CLE | 15 | 2 | 0 | 5 | 22 | 19 | 41 | 2 | 0 | 0 | 0 | 0 | 0 |
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| #47Marcus Williams | FS | NO | 16 | 2 | 0 | 8 | 50 | 22 | 72 | 0 | 0 | 1 | 0 | 0 | 0 |
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| #47Mike Hilton | CB | CIN | 17 | 2 | 0 | 5 | 43 | 18 | 61 | 7 | 2 | 1 | 0 | 1 | 0 |
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| #47Minkah Fitzpatrick | FS | PIT | 16 | 2 | 0 | 7 | 76 | 40 | 116 | 1 | 0 | 1 | 0 | 0 | 0 |
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| #47Nick Scott | SAF | LAR | 16 | 2 | 0 | 4 | 26 | 19 | 45 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Nik Needham | DB | MIA | 15 | 2 | 1 | 5 | 42 | 11 | 53 | 1 | 2 | 0 | 0 | 1 | 10 |
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| #47Pierre Desir | CB | TB | 9 | 2 | 0 | 4 | 24 | 2 | 26 | 0 | 0 | 1 | 0 | 0 | 0 |
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| #47Rashaan Evans | ILB | TEN | 12 | 2 | 0 | 2 | 29 | 22 | 51 | 2 | 0 | 1 | 0 | 0 | 0 |
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| #47Rodney McLeod Jr. | FS | PHI | 13 | 2 | 0 | 4 | 31 | 26 | 57 | 0 | 0 | 0 | 0 | 0 | 0 |
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| #47Shaq Thompson | OLB | CAR | 14 | 2 | 2 | 5 | 58 | 39 | 97 | 7 | 6 | 0 | 0 | 0 | 18 |
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| #47Stephon Gilmore | CB | CAR | 7 | 2 | 0 | 2 | 12 | 1 | 13 | 1 | 0 | 0 | 0 | 0 | 0 |
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| #47Tae Crowder | LB | NYG | 17 | 2 | 0 | 6 | 53 | 66 | 119 | 2 | 1 | 1 | 1 | 0 | 0 |
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| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Buffalo Bills | 3–1 | .750 | +20 |
| New England Patriots | 2–2 | .500 | -12 |
| New York Jets | 1–3 | .250 | -8 |
| Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Baltimore Ravens | 3–1 | .750 | +20 |
| Cleveland Browns | 3–1 | .750 | -14 |
| Cincinnati Bengals | 2–2 | .500 | +12 |
| Pittsburgh Steelers | 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Jacksonville Jaguars | 3–1 | .750 | +51 |
| Indianapolis Colts | 2–2 | .500 | -2 |
| Houston Texans | 0–4 | .000 | -25 |
| Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Kansas City Chiefs | 4–0 | 1.000 | +41 |
 Las Vegas Raiders | 3–1 | .750 | +31 |
| Denver Broncos | 2–2 | .500 | -20 |
| Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| New York Giants | 3–1 | .750 | +3 |
| Dallas Cowboys | 2–2 | .500 | +10 |
| Philadelphia Eagles | 2–2 | .500 | -18 |
| Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Minnesota Vikings | 4–0 | 1.000 | +35 |
| Chicago Bears | 3–1 | .750 | +47 |
| Detroit Lions | 2–2 | .500 | -8 |
| Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Carolina Panthers | 2–2 | .500 | +12 |
| Atlanta Falcons | 2–2 | .500 | +4 |
| New Orleans Saints | 1–3 | .250 | -23 |
| Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| San Francisco 49ers | 4–0 | 1.000 | +58 |
| Seattle Seahawks | 3–1 | .750 | +32 |
| Los Angeles Rams | 2–2 | .500 | +2 |
| Arizona Cardinals | 1–3 | .250 | -30 |
