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The NFL players with the most safeties in the 2010 season.
| Player | POS | Team | GP | SAF | SCK | DEF INT | PD | SOLO | AST | TOT TKL | QBH | FF | SCKY |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1Brandon Siler | ILB |  LAC | 11 | 1 | 1 | 1 | 2 | 28 | 10 | 38 | 3 | 0 | 7 |
| #1Eugene Sims | DE |  LAR | 7 | 1 | 0 | 0 | 1 | 6 | 2 | 8 | 1 | 0 | |
| #1Greg Hardy | DE |  CAR | 15 | 1 | 3 | 0 | 1 | 18 | 6 | 24 | 9 | 2 | |
| #1Jason Taylor | OLB |  NYJ | 16 | 1 | 5 | 0 | 6 | 20 | 11 | 31 | 6 | 2 | |
| #1Jordan Babineaux | S |  SEA | 16 | 1 | 1.5 | 2 | 8 | 30 | 9 | 39 | 4 | 1 | |
| #1Nicholas Schommer | SAF |  TEN | 4 | 1 | 0 | 0 | 0 | 3 | 0 | 3 | 0 | 0 | |
| #1Quentin Groves | OLB |  LV | 13 | 1 | 0 | 1 | 2 | 24 | 11 | 35 | 1 | 0 | |
| #1Rock Cartwright | RB | LV | 15 | 1 | 0 | 0 | 0 | 14 | 2 | 16 | 0 | 1 | |
| #1Trevor Pryce | DE | 6 | 1 | 1 | 0 | 0 | 2 | 1 | 3 | 5 | 0 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Buffalo Bills | 3–1 | .750 | +20 |
 New England Patriots | 2–2 | .500 | -12 |
| New York Jets | 1–3 | .250 | -8 |
 Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Baltimore Ravens | 3–1 | .750 | +20 |
 Cleveland Browns | 3–1 | .750 | -14 |
 Cincinnati Bengals | 2–2 | .500 | +12 |
 Pittsburgh Steelers | 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Jacksonville Jaguars | 3–1 | .750 | +51 |
 Indianapolis Colts | 2–2 | .500 | -2 |
 Houston Texans | 0–4 | .000 | -25 |
| Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Kansas City Chiefs | 4–0 | 1.000 | +41 |
| Las Vegas Raiders | 3–1 | .750 | +31 |
 Denver Broncos | 2–2 | .500 | -20 |
| Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 New York Giants | 3–1 | .750 | +3 |
 Dallas Cowboys | 2–2 | .500 | +10 |
 Philadelphia Eagles | 2–2 | .500 | -18 |
 Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Minnesota Vikings | 4–0 | 1.000 | +35 |
 Chicago Bears | 3–1 | .750 | +47 |
 Detroit Lions | 2–2 | .500 | -8 |
 Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| Carolina Panthers | 2–2 | .500 | +12 |
 Atlanta Falcons | 2–2 | .500 | +4 |
 New Orleans Saints | 1–3 | .250 | -23 |
 Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 San Francisco 49ers | 4–0 | 1.000 | +58 |
| Seattle Seahawks | 3–1 | .750 | +32 |
| Los Angeles Rams | 2–2 | .500 | +2 |
 Arizona Cardinals | 1–3 | .250 | -30 |
