11–6 · #2 in NFC West · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| A.J. Green | WR | — | — | 2011 | Active |
| Aaron Brewer | LS | — | — | 2012 | Active |
| Andy Isabella | WR | — | — | 2019 | Active |
| Andy Lee | P | — | — | 2004 | Active |
| Antoine Wesley | WR | — | — | 2021 | Active |
| Antonio Hamilton | CB | — | — | 2016 | Active |
| Beau Brinkley | LS | — | — | 2012 | Active |
| Breon Borders | CB | — | — | 2018 | Active |
| Brian Winters | G | — | — | 2013 | Active |
| Budda Baker | S | — | — | 2017 | Active |
| Byron Murphy | CB | — | — | 2019 | Active |
| Chandler Jones | DE | — | — | 2012 | Active |
| Charles Washington | DB | — | — | 2017 | Active |
| Chase Edmonds | RB | — | — | 2018 | Active |
| Chris Banjo | DB | — | — | 2013 | Active |
| Chris Streveler | QB | — | — | 2020 | Active |
| Christian Kirk | WR | — | — | 2018 | Active |
| Colt McCoy | QB | — | — | 2010 | Active |
| Corey Peters | DE | — | — | 2010 | Active |
| D.J. Humphries | OT | — | — | 2016 | Active |
| Danny Isidora | G | — | — | 2017 | Active |
| Darrell Daniels | TE | — | — | 2017 | Active |
| David Wells | TE | — | — | 2021 | Active |
| DeAndre Hopkins | WR | — | — | 2013 | Active |
| Deionte Thompson | SAF | — | — | 2019 | Active |
| Demetrius Harris | TE | — | — | 2014 | Active |
| Dennis Gardeck | LB | — | — | 2018 | Active |
| Devon Kennard | OLB | — | — | 2014 | Active |
| Eno Benjamin | RB | — | — | 2021 | Active |
| Eric Smith | OT | — | — | 2019 | Active |
| Ezekiel Turner | LB | — | — | 2018 | Active |
| Greg Dortch | WR | — | — | 2019 | Active |
| Isaiah Simmons | SAF | — | — | 2020 | Active |
| J.J. Watt | DE | — | — | 2011 | Active |
| Jace Whittaker | CB | — | — | 2020 | Active |
| Jalen Thompson | DB | — | — | 2019 | Active |
| James Conner | RB | — | — | 2017 | Active |
| James Wiggins | SAF | — | — | 2021 | Active |
| Joe Walker | LB | — | — | 2017 | Active |
| Jonathan Ledbetter | DE | — | — | 2019 | Active |
| Jonathan Ward | RB | — | — | 2020 | Active |
| Jordan Hicks | MLB | — | — | 2015 | Active |
| Jordan Phillips | DT | — | — | 2015 | Active |
| Josh Jones | OT | — | — | 2020 | Active |
| Josh Mauro | DE | — | — | 2014 | Active |
| Joshua Miles | OT | — | — | 2019 | Active |
| Justin Murray | OT | — | — | 2018 | Active |
| Justin Pugh | G | — | — | 2013 | Active |
| Kelvin Beachum | OT | — | — | 2012 | Active |
| Kevin Peterson | CB | — | — | 2017 | Active |
| Koda Martin | G | — | — | 2021 | Active |
| Kyler Murray | QB | — | — | 2019 | Active |
| Kylie Fitts | LB | — | — | 2018 | Active |
| Leki Fotu | DT | — | — | 2020 | Active |
| Marco Wilson | CB | — | — | 2021 | Active |
| Markus Golden | LB | — | — | 2015 | Active |
| Matt Prater | K | — | — | 2007 | Active |
| Max Garcia | G | — | — | 2015 | Active |
| Maxx Williams | TE | — | — | 2015 | Active |
| Michael Dogbe | DE | — | — | 2019 | Active |
| Rashard Lawrence | DT | — | — | 2020 | Active |
| Robert Alford | CB | — | — | 2013 | Active |
| Rodney Hudson | C | — | — | 2011 | Active |
| Rondale Moore | WR | — | — | 2021 | Active |
| Ross Travis | TE | — | — | 2016 | Active |
| Ryan Winslow | P | — | — | 2019 | Active |
| Sean Harlow | C | — | — | 2019 | Active |
| Tahir Whitehead | OLB | — | — | 2012 | Active |
| Tanner Vallejo | ILB | — | — | 2017 | Active |
| Tavien Feaster | RB | — | — | 2021 | Active |
| Victor Dimukeje | LB | — | — | 2021 | Active |
| Zach Allen | DE | — | — | 2019 | Active |
| Zach Ertz | TE | — | — | 2013 | Active |
| Zach Kerr | DE | — | — | 2014 | Active |
| Zaven Collins | LB | — | — | 2021 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |