7–10 · #4 in AFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Aaron Patrick | LB | — | — | 2021 | Active |
| Albert Okwuegbunam | TE | — | — | 2020 | Active |
| Alexander Johnson | LB | — | — | 2018 | Active |
| Andre Mintze | LB | — | — | 2021 | Active |
| Andrew Beck | FB | — | — | 2019 | Active |
| Austin Schlottmann | C | — | — | 2019 | Active |
| Baron Browning | LB | — | — | 2021 | Active |
| Barrington Wade | LB | — | — | 2021 | Active |
| Bobby Massie | OT | — | — | 2012 | Active |
| Bradley Chubb | OLB | — | — | 2018 | Active |
| Brandon McManus | K | — | — | 2014 | Active |
| Brett Rypien | QB | — | — | 2020 | Active |
| Bryce Callahan | CB | — | — | 2015 | Active |
| Caden Sterns | SAF | — | — | 2021 | Active |
| Calvin Anderson | OT | — | — | 2020 | Active |
| Cameron Fleming | OT | — | — | 2014 | Active |
| Courtland Sutton | WR | — | — | 2018 | Active |
| Curtis Robinson | LB | — | — | 2021 | Active |
| Dalton Risner | G | — | — | 2019 | Active |
| Damarea Crockett | RB | — | — | 2021 | Active |
| David Moore | WR | — | — | 2017 | Active |
| DeShawn Williams | DE | — | — | 2016 | Active |
| Diontae Spencer | WR | — | — | 2019 | Active |
| Dre'Mont Jones | LB | — | — | 2019 | Active |
| Drew Lock | QB | — | — | 2019 | Active |
| Eric Saubert | TE | — | — | 2017 | Active |
| Essang Bassey | DB | — | — | 2020 | Active |
| Garett Bolles | OT | — | — | 2017 | Active |
| Graham Glasgow | C | — | — | 2016 | Active |
| Jacob Bobenmoyer | LS | — | — | 2020 | Active |
| Jamar Johnson | SAF | — | — | 2021 | Active |
| Javonte Williams | RB | — | — | 2021 | Active |
| Jerry Jeudy | WR | — | — | 2020 | Active |
| John Brown | WR | — | — | 2014 | Active |
| Jonas Griffith | LB | — | — | 2021 | Active |
| Jonathan Harris | DT | — | — | 2019 | Active |
| Jonathon Cooper | LB | — | — | 2021 | Active |
| Josey Jewell | ILB | — | — | 2018 | Active |
| Justin Simmons | FS | — | — | 2016 | Active |
| Justin Strnad | LB | — | — | 2021 | Active |
| Kareem Jackson | S | — | — | 2010 | Active |
| Kendall Hinton | WR | — | — | 2020 | Active |
| Kenny Young | ILB | — | — | 2018 | Active |
| KJ Hamler | WR | — | — | 2020 | Active |
| Kyle Fuller | CB | — | — | 2014 | Active |
| Lloyd Cushenberry III | C | — | — | 2020 | Active |
| Malik Reed | LB | — | — | 2019 | Active |
| Marquiss Spencer | DE | — | — | 2021 | Active |
| McTelvin Agim | DT | — | — | 2020 | Active |
| Melvin Gordon | RB | — | — | 2015 | Active |
| Micah Kiser | LB | — | — | 2018 | Active |
| Michael Ojemudia | CB | — | — | 2020 | Active |
| Mike Boone | RB | — | — | 2018 | Active |
| Mike Ford | DB | — | — | 2018 | Active |
| Mike Purcell | NT | — | — | 2014 | Active |
| Nate Hairston | CB | — | — | 2017 | Active |
| Netane Muti | G | — | — | 2020 | Active |
| Noah Fant | TE | — | — | 2019 | Active |
| P.J. Locke | DB | — | — | 2020 | Active |
| Pat Surtain II | CB | — | — | 2021 | Active |
| Pita Taumoepenu | LB | — | — | 2017 | Active |
| Quinn Bailey | OT | — | — | 2019 | Active |
| Quinn Meinerz | C | — | — | 2021 | Active |
| Rojesterman Farris | DB | — | — | 2021 | Active |
| Ronald Darby | CB | — | — | 2015 | Active |
| Sam Martin | P | — | — | 2013 | Active |
| Seth Williams | WR | — | — | 2021 | Active |
| Shamar Stephen | DT | — | — | 2014 | Active |
| Shelby Harris | DE | — | — | 2014 | Active |
| Stephen Weatherly | DE | — | — | 2016 | Active |
| Teddy Bridgewater | QB | — | — | 2014 | Active |
| Tim Patrick | WR | — | — | 2018 | Active |
| Travis Fulgham | WR | — | — | 2019 | Active |
| Tyrie Cleveland | WR | — | — | 2020 | Active |
| Von Miller | OLB | — | — | 2011 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |