12–4 · #1 in AFC South · Lost Divisional RoundChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alan Ball | CB | — | — | 2007 | Active |
| Andre Johnson | WR | — | — | 2003 | Active |
| Andrew Gardner | G | — | — | 2012 | Active |
| Antoine Caldwell | G | — | — | 2011 | Active |
| Antonio Smith | DE | — | — | 2005 | Active |
| Arian Foster | RB | — | — | 2009 | Active |
| Barrett Ruud | ILB | — | — | 2005 | Active |
| Ben Jones | C | — | — | 2012 | Active |
| Ben Tate | RB | — | — | 2011 | Active |
| Bradie James | ILB | — | — | 2003 | Active |
| Brandon Brooks | G | — | — | 2012 | Active |
| Brandon Harris | DB | — | — | 2011 | Active |
| Brian Cushing | ILB | — | — | 2009 | Active |
| Brice McCain | CB | — | — | 2009 | Active |
| Brooks Reed | LB | — | — | 2011 | Active |
| Bryan Braman | LB | — | — | 2011 | Active |
| Chris Myers | C | — | — | 2007 | Active |
| Connor Barwin | ILB | — | — | 2009 | Active |
| Danieal Manning | S | — | — | 2006 | Active |
| Darryl Sharpton | ILB | — | — | 2010 | Active |
| Derek Newton | OT | — | — | 2011 | Active |
| DeVier Posey | WR | — | — | 2012 | Active |
| Donnie Jones | P | — | — | 2004 | Active |
| Duane Brown | OT | — | — | 2008 | Active |
| Earl Mitchell | DT | — | — | 2010 | Active |
| Eddie Pleasant | DB | — | — | 2012 | Active |
| Garrett Graham | TE | — | — | 2010 | Active |
| Glover Quin | FS | — | — | 2009 | Active |
| J.J. Watt | DE | — | — | 2011 | Active |
| James Casey | TE | — | — | 2009 | Active |
| Jared Crick | DE | — | — | 2012 | Active |
| Jesse Nading | LB | — | — | 2008 | Active |
| Johnathan Joseph | CB | — | — | 2006 | Active |
| Jon Weeks | LS | — | — | 2010 | Active |
| Justin Forsett | RB | — | — | 2008 | Active |
| Kareem Jackson | S | — | — | 2010 | Active |
| Keshawn Martin | WR | — | — | 2012 | Active |
| Kevin Walter | WR | — | — | 2003 | Active |
| Lestar Jean | WR | — | — | 2012 | Active |
| Matt Schaub | QB | — | — | 2004 | Active |
| Mister Alexander | LB | — | — | 2011 | Active |
| Owen Daniels | TE | — | — | 2006 | Active |
| Quintin Demps | S | — | — | 2008 | Active |
| Roc Carmichael | DB | — | — | 2012 | Active |
| Ryan Harris | OT | — | — | 2008 | Active |
| Shaun Cody | NT | — | — | 2005 | Active |
| Shayne Graham | K | — | — | 2001 | Active |
| Shiloh Keo | DB | — | — | 2011 | Active |
| Stanford Routt | CB | — | — | 2005 | Active |
| T.J. Yates | QB | — | — | 2011 | Active |
| Tim Dobbins | LB | — | — | 2006 | Active |
| Tim Jamison | NT | — | — | 2009 | Active |
| Trindon Holliday | WR | — | — | 2011 | Active |
| Troy Nolan | DB | — | — | 2010 | Active |
| Tyler Clutts | FB | — | — | 2011 | Active |
| Wade Smith | OT | — | — | 2007 | Active |
| Whitney Mercilus | DE | — | — | 2012 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |