11–5 · #1 in AFC South · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Al-Quadin Muhammad | LB | — | — | 2017 | Active |
| Anthony Castonzo | OT | — | — | 2011 | Active |
| Anthony Walker | MLB | — | — | 2017 | Active |
| Ashton Dulin | WR | — | — | 2019 | Active |
| Ben Banogu | DE | — | — | 2019 | Active |
| Bobby Okereke | ILB | — | — | 2019 | Active |
| Braden Smith | OT | — | — | 2018 | Active |
| Cassius Marsh | LB | — | — | 2014 | Active |
| Chaz Green | OT | — | — | 2016 | Active |
| Danny Pinter | G | — | — | 2020 | Active |
| Daurice Fountain | WR | — | — | 2018 | Active |
| De'Michael Harris | WR | — | — | 2020 | Active |
| DeForest Buckner | DT | — | — | 2016 | Active |
| Denico Autry | DT | — | — | 2014 | Active |
| Dezmon Patmon | WR | — | — | 2020 | Active |
| E.J. Speed | LB | — | — | 2019 | Active |
| Farrod Green | TE | — | — | 2020 | Active |
| George Odum | DB | — | — | 2018 | Active |
| Grover Stewart | DT | — | — | 2017 | Active |
| Ibraheim Campbell | DB | — | — | 2015 | Active |
| Isaiah Rodgers | CB | — | — | 2020 | Active |
| J'Marcus Webb | OT | — | — | 2010 | Active |
| Jack Doyle | TE | — | — | 2013 | Active |
| Jacoby Brissett | QB | — | — | 2016 | Active |
| Jake Eldrenkamp | G | — | — | 2020 | Active |
| Jared Veldheer | OT | — | — | 2010 | Active |
| Joey Hunt | C | — | — | 2016 | Active |
| Jonathan Taylor | RB | — | — | 2020 | Active |
| Jordan Glasgow | LB | — | — | 2020 | Active |
| Jordan Wilkins | RB | — | — | 2018 | Active |
| Julian Blackmon | SAF | — | — | 2020 | Active |
| Justin Houston | OLB | — | — | 2011 | Active |
| Kameron Cline | DE | — | — | 2020 | Active |
| Kemoko Turay | DE | — | — | 2018 | Active |
| Kenny Moore II | CB | — | — | 2017 | Active |
| Khari Willis | S | — | — | 2019 | Active |
| Le'Raven Clark | OT | — | — | 2016 | Active |
| Luke Rhodes | LS | — | — | 2016 | Active |
| Malik Hooker | FS | — | — | 2017 | Active |
| Marcus Johnson | WR | — | — | 2017 | Active |
| Mark Glowinski | G | — | — | 2015 | Active |
| Marlon Mack | RB | — | — | 2017 | Active |
| Matthew Adams | OLB | — | — | 2018 | Active |
| Michael Pittman | WR | — | — | 2020 | Active |
| Mo Alie-Cox | TE | — | — | 2018 | Active |
| Noah Togiai | TE | — | — | 2020 | Active |
| Nyheim Hines | RB | — | — | 2018 | Active |
| Parris Campbell | WR | — | — | 2019 | Active |
| Philip Rivers | QB | — | — | 2004 | Active |
| Quenton Nelson | G | — | — | 2018 | Active |
| Rigoberto Sanchez | P | — | — | 2017 | Active |
| Rob Windsor | DT | — | — | 2020 | Active |
| Rock Ya-Sin | CB | — | — | 2019 | Active |
| Rodrigo Blankenship | K | — | — | 2020 | Active |
| Ryan Allen | P | — | — | 2013 | Active |
| Ryan Kelly | C | — | — | 2016 | Active |
| Shaquille Leonard | OLB | — | — | 2018 | Active |
| Sheldon Day | DT | — | — | 2016 | Active |
| T.J. Carrie | DB | — | — | 2014 | Active |
| T.Y. Hilton | WR | — | — | 2012 | Active |
| Tavon Wilson | FS | — | — | 2012 | Active |
| Taylor Stallworth | DT | — | — | 2018 | Active |
| Tremon Smith | CB | — | — | 2018 | Active |
| Trey Burton | TE | — | — | 2014 | Active |
| Tyquan Lewis | DE | — | — | 2018 | Active |
| Will Holden | G | — | — | 2017 | Active |
| Xavier Rhodes | CB | — | — | 2013 | Active |
| Zach Pascal | WR | — | — | 2018 | Active |
| Zaire Franklin | OLB | — | — | 2018 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |