10–7 · #2 in AFC West · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| AJ Cole | P | — | — | 2019 | Active |
| Alec Ingold | FB | — | — | 2019 | Active |
| Alex Leatherwood | OT | — | — | 2021 | Active |
| Amik Robertson | CB | — | — | 2020 | Active |
| Andre James | OT | — | — | 2019 | Active |
| Brandon Facyson | DB | — | — | 2018 | Active |
| Brandon Parker | OT | — | — | 2018 | Active |
| Bryan Edwards | WR | — | — | 2020 | Active |
| Carl Nassib | LB | — | — | 2016 | Active |
| Carson Tinker | LS | — | — | 2013 | Active |
| Casey Hayward | CB | — | — | 2012 | Active |
| Clelin Ferrell | DE | — | — | 2019 | Active |
| Cory Littleton | ILB | — | — | 2016 | Active |
| Dallin Leavitt | DB | — | — | 2018 | Active |
| Damion Square | DT | — | — | 2013 | Active |
| Damon Arnette | CB | — | — | 2020 | Active |
| Daniel Carlson | K | — | — | 2018 | Active |
| Daniel Helm | TE | — | — | 2020 | Active |
| Darius Philon | DT | — | — | 2015 | Active |
| Darren Waller | TE | — | — | 2015 | Active |
| Denzel Perryman | MLB | — | — | 2015 | Active |
| Denzelle Good | G | — | — | 2015 | Active |
| Derek Carr | QB | — | — | 2014 | Active |
| Derek Carrier | TE | — | — | 2013 | Active |
| DeSean Jackson | WR | — | — | 2008 | Active |
| Desmond Trufant | CB | — | — | 2013 | Active |
| Dillon Stoner | WR | — | — | 2021 | Active |
| Divine Deablo | LB | — | — | 2021 | Active |
| Foster Moreau | TE | — | — | 2019 | Active |
| Gerald McCoy | DT | — | — | 2010 | Active |
| Ha Ha Clinton-Dix | S | — | — | 2014 | Active |
| Henry Ruggs III | WR | — | — | 2020 | Active |
| Hunter Renfrow | WR | — | — | 2019 | Active |
| Jackson Barton | OT | — | — | 2021 | Active |
| Jalen Richard | RB | — | — | 2016 | Active |
| Javin White | DB | — | — | 2020 | Active |
| Jermaine Eluemunor | G | — | — | 2017 | Active |
| John Simpson | G | — | — | 2020 | Active |
| Johnathan Abram | DB | — | — | 2019 | Active |
| Johnathan Hankins | DT | — | — | 2013 | Active |
| Jordan Simmons | G | — | — | 2018 | Active |
| Josh Jacobs | RB | — | — | 2019 | Active |
| K.J. Wright | OLB | — | — | 2011 | Active |
| Kavon Frazier | FS | — | — | 2016 | Active |
| Keisean Nixon | DB | — | — | 2019 | Active |
| Kendal Vickers | DE | — | — | 2020 | Active |
| Kenyan Drake | RB | — | — | 2016 | Active |
| Kolton Miller | OT | — | — | 2018 | Active |
| Kyle Wilber | LB | — | — | 2012 | Active |
| Lester Cotton | G | — | — | 2019 | Active |
| Malcolm Koonce | DE | — | — | 2021 | Active |
| Marcell Ateman | WR | — | — | 2018 | Active |
| Marcus Mariota | QB | — | — | 2015 | Active |
| Marquel Lee | MLB | — | — | 2017 | Active |
| Matt Bushman | TE | — | — | 2021 | Active |
| Maxx Crosby | DE | — | — | 2019 | Active |
| Nate Hobbs | CB | — | — | 2021 | Active |
| Nathan Peterman | QB | — | — | 2017 | Active |
| Nick Bowers | TE | — | — | 2021 | Active |
| Nick Kwiatkoski | ILB | — | — | 2016 | Active |
| Nick Martin | C | — | — | 2017 | Active |
| Patrick Onwuasor | ILB | — | — | 2016 | Active |
| Peyton Barber | RB | — | — | 2016 | Active |
| Quinton Jefferson | DE | — | — | 2016 | Active |
| Roderic Teamer | DB | — | — | 2019 | Active |
| Solomon Thomas | DE | — | — | 2017 | Active |
| Sutton Smith | RB | — | — | 2021 | Active |
| Trayvon Mullen | CB | — | — | 2019 | Active |
| Tre'von Moehrig | SAF | — | — | 2021 | Active |
| Trent Sieg | LS | — | — | 2018 | Active |
| Trey Ragas | RB | — | — | 2021 | Active |
| Tyree Gillespie | SAF | — | — | 2021 | Active |
| Tyron Johnson | WR | — | — | 2020 | Active |
| Will Compton | ILB | — | — | 2013 | Active |
| Willie Snead | WR | — | — | 2015 | Active |
| Yannick Ngakoue | DE | — | — | 2016 | Active |
| Zay Jones | WR | — | — | 2017 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |