9–7 · #2 in AFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Adam Terry | OT | — | — | 2005 | Active |
| Antoine Cason | CB | — | — | 2008 | Active |
| Antonio Garay | DE | — | — | 2003 | Active |
| Antonio Gates | TE | — | — | 2003 | Active |
| Antwan Applewhite | DE | — | — | 2008 | Active |
| Antwan Barnes | LB | — | — | 2007 | Active |
| Billy Latsko | RB | — | — | 2010 | Active |
| Billy Volek | QB | — | — | 2001 | Active |
| Brandon Lang | LB | — | — | 2010 | Active |
| Brandon Moore | LB | — | — | 2002 | Active |
| Brandon Siler | ILB | — | — | 2007 | Active |
| Brandyn Dombrowski | OT | — | — | 2009 | Active |
| C.J. Spillman | DB | — | — | 2009 | Active |
| Cam Thomas | DT | — | — | 2010 | Active |
| Craig Davis | WR | — | — | 2007 | Active |
| Curtis Brinkley | RB | — | — | 2010 | Active |
| Cyril Obiozor | LB | — | — | 2009 | Active |
| Dante Hughes | DB | — | — | 2007 | Active |
| Darren Sproles | RB | — | — | 2005 | Active |
| Darry Beckwith | LB | — | — | 2010 | Active |
| David Herron | LB | — | — | 2007 | Active |
| Donald Strickland | DB | — | — | 2003 | Active |
| Eric Weddle | FS | — | — | 2007 | Active |
| Fred Bennett | DB | — | — | 2007 | Active |
| Gary Banks | WR | — | — | 2010 | Active |
| Jacob Hester | RB | — | — | 2008 | Active |
| Jacques Cesaire | DE | — | — | 2003 | Active |
| James Holt | LB | — | — | 2009 | Active |
| Jeromey Clary | G | — | — | 2007 | Active |
| Jyles Tucker | OLB | — | — | 2007 | Active |
| Kelley Washington | WR | — | — | 2003 | Active |
| Kevin Burnett | OLB | — | — | 2005 | Active |
| Kion Wilson | LB | — | — | 2010 | Active |
| Kory Sperry | TE | — | — | 2009 | Active |
| Kris Brown | K | — | — | — | Active |
| Kris Dielman | G | — | — | 2003 | Active |
| Kris Wilson | TE | — | — | 2004 | Active |
| Larry English | DE | — | — | 2009 | Active |
| Legedu Naanee | WR | — | — | 2007 | Active |
| Louis Vasquez | G | — | — | 2009 | Active |
| Luis Castillo | DE | — | — | 2005 | Active |
| Malcom Floyd | WR | — | — | 2004 | Active |
| Marcus McNeill | OT | — | — | 2006 | Active |
| Mike Scifres | P | — | — | 2003 | Active |
| Mike Tolbert | FB | — | — | 2008 | Active |
| Mike Windt | LS | — | — | 2010 | Active |
| Nate Kaeding | K | — | — | 2004 | Active |
| Nick Hardwick | C | — | — | 2004 | Active |
| Ogemdi Nwagbuo | DT | — | — | 2009 | Active |
| Pat Watkins | DB | — | — | 2006 | Active |
| Patrick Crayton | WR | — | — | 2004 | Active |
| Paul Oliver | S | — | — | 2008 | Active |
| Philip Rivers | QB | — | — | 2004 | Active |
| Quentin Jammer | CB | — | — | 2002 | Active |
| Quinton Teal | DB | — | — | 2007 | Active |
| Randy McMichael | TE | — | — | 2002 | Active |
| Richard Goodman | WR | — | — | 2010 | Active |
| Ryan Mathews | RB | — | — | 2010 | Active |
| Seyi Ajirotutu | WR | — | — | 2010 | Active |
| Shaun Phillips | OLB | — | — | 2004 | Active |
| Shawne Merriman | DE | — | — | 2005 | Active |
| Stephen Cooper | LB | — | — | 2003 | Active |
| Steve Gregory | S | — | — | 2006 | Active |
| Travis Johnson | DE | — | — | 2005 | Active |
| Tyrone Carter | DB | — | — | — | Active |
| Tyronne Green | G | — | — | 2010 | Active |
| Vaughn Martin | DE | — | — | 2009 | Active |
| Vincent Jackson | WR | — | — | 2005 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |