10–7 · #2 in AFC West · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alohi Gilman | SAF | — | — | 2020 | Active |
| Amen Ogbongbemiga | LB | — | — | 2021 | Active |
| Asante Samuel Jr. | CB | — | — | 2021 | Active |
| Austin Ekeler | RB | — | — | 2017 | Active |
| Austin Johnson | NT | — | — | 2016 | Active |
| Breiden Fehoko | DT | — | — | 2020 | Active |
| Brenden Jaimes | OT | — | — | 2021 | Active |
| Bryce Callahan | CB | — | — | 2015 | Active |
| Cameron Dicker | K | — | — | 2022 | Active |
| Chase Daniel | QB | — | — | 2010 | Active |
| Chris Rumph II | LB | — | — | 2021 | Active |
| Christian Covington | DE | — | — | 2015 | Active |
| Christopher Hinton | DT | — | — | 2022 | Active |
| Corey Linsley | C | — | — | 2014 | Active |
| David Moa | DT | — | — | 2021 | Active |
| DeAndre Carter | WR | — | — | 2018 | Active |
| Deane Leonard | CB | — | — | 2022 | Active |
| Derrek Tuszka | LB | — | — | 2020 | Active |
| Derwin James | FS | — | — | 2018 | Active |
| Donald Parham | TE | — | — | 2020 | Active |
| Drue Tranquill | LB | — | — | 2019 | Active |
| Dustin Hopkins | K | — | — | 2015 | Active |
| Foster Sarell | OT | — | — | 2022 | Active |
| Gerald Everett | TE | — | — | 2017 | Active |
| Isaiah Spiller | RB | — | — | 2022 | Active |
| J.C. Jackson | DB | — | — | 2018 | Active |
| J.K. Scott | P | — | — | 2018 | Active |
| Ja'Sir Taylor | CB | — | — | 2022 | Active |
| Jalen Guyton | WR | — | — | 2019 | Active |
| Jamaree Salyer | G | — | — | 2022 | Active |
| Jason Moore | WR | — | — | 2019 | Active |
| Jeremiah Attaochu | LB | — | — | 2014 | Active |
| Jerry Tillery | DT | — | — | 2019 | Active |
| Joe Gaziano | DE | — | — | 2020 | Active |
| Joey Bosa | DE | — | — | 2016 | Active |
| Josh Harris | LS | — | — | 2012 | Active |
| Josh Palmer | WR | — | — | 2021 | Active |
| Joshua Kelley | RB | — | — | 2020 | Active |
| JT Woods | SAF | — | — | 2022 | Active |
| Justin Herbert | QB | — | — | 2020 | Active |
| Keenan Allen | WR | — | — | 2013 | Active |
| Kemon Hall | DB | — | — | 2021 | Active |
| Kenneth Murray, Jr. | LB | — | — | 2020 | Active |
| Khalil Mack | OLB | — | — | 2014 | Active |
| Kyle Van Noy | MLB | — | — | 2014 | Active |
| Larry Rountree III | RB | — | — | 2021 | Active |
| Matt Feiler | G | — | — | 2017 | Active |
| Michael Bandy | WR | — | — | 2021 | Active |
| Michael Davis | CB | — | — | 2017 | Active |
| Mike Williams | WR | — | — | 2017 | Active |
| Morgan Fox | DE | — | — | 2016 | Active |
| Nasir Adderley | FS | — | — | 2019 | Active |
| Nick Niemann | LB | — | — | 2021 | Active |
| Otito Ogbonnia | DT | — | — | 2022 | Active |
| Raheem Layne | SAF | — | — | 2022 | Active |
| Rashawn Slater | OT | — | — | 2021 | Active |
| Richard Rodgers | TE | — | — | 2014 | Active |
| Sebastian Joseph-Day | DT | — | — | 2019 | Active |
| Sony Michel | RB | — | — | 2018 | Active |
| Stone Smartt | TE | — | — | 2022 | Active |
| Storm Norton | OT | — | — | 2018 | Active |
| Taylor Bertolet | K | — | — | 2022 | Active |
| Tre' McKitty | TE | — | — | 2021 | Active |
| Trey Pipkins | OT | — | — | 2019 | Active |
| Troy Reeder | LB | — | — | 2019 | Active |
| Tyeler Davison | DT | — | — | 2015 | Active |
| Will Clapp | C | — | — | 2018 | Active |
| Zack Bailey | G | — | — | 2022 | Active |
| Zander Horvath | RB | — | — | 2022 | Active |
| Zion Johnson | G | — | — | 2022 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |