11–6 · #2 in AFC West · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alohi Gilman | SAF | — | — | 2020 | Active |
| Amar Johnson | RB | — | — | 2025 | Active |
| Andre James | OT | — | — | 2019 | Active |
| Austin Deculus | OT | — | — | 2022 | Active |
| Benjamin St-Juste | CB | — | — | 2021 | Active |
| Bobby Hart | OT | — | — | 2015 | Active |
| Bradley Bozeman | C | — | — | 2018 | Active |
| Branson Taylor | OT | — | — | 2025 | Active |
| Bud Dupree | OLB | — | — | 2015 | Active |
| Caleb Murphy | LB | — | — | 2023 | Active |
| Cam Hart | CB | — | — | 2024 | Active |
| Cameron Dicker | K | — | — | 2022 | Active |
| Clelin Ferrell | DE | — | — | 2019 | Active |
| Da'Shawn Hand | DE | — | — | 2018 | Active |
| Daiyan Henley | LB | — | — | 2023 | Active |
| David Sharpe | OT | — | — | 2017 | Active |
| Deane Leonard | CB | — | — | 2022 | Active |
| Del'Shawn Phillips | LB | — | — | 2020 | Active |
| Denzel Perryman | MLB | — | — | 2015 | Active |
| Derius Davis | WR | — | — | 2023 | Active |
| Derwin James | FS | — | — | 2018 | Active |
| Donte Jackson | CB | — | — | 2018 | Active |
| Elijah Molden | CB | — | — | 2021 | Active |
| Foster Sarell | OT | — | — | 2022 | Active |
| Hassan Haskins | RB | — | — | 2022 | Active |
| J.K. Scott | P | — | — | 2018 | Active |
| Ja'Sir Taylor | CB | — | — | 2022 | Active |
| Jamaree Caldwell | DT | — | — | 2025 | Active |
| Jamaree Salyer | G | — | — | 2022 | Active |
| Jaret Patterson | RB | — | — | 2021 | Active |
| Joe Alt | OT | — | — | 2024 | Active |
| Josh Harris | LS | — | — | 2012 | Active |
| Justin Eboigbe | DT | — | — | 2024 | Active |
| Justin Herbert | QB | — | — | 2020 | Active |
| KeAndre Lambert-Smith | WR | — | — | 2025 | Active |
| Keenan Allen | WR | — | — | 2013 | Active |
| Kendall Williamson | SAF | — | — | 2024 | Active |
| Khalil Mack | OLB | — | — | 2014 | Active |
| Kimani Vidal | RB | — | — | 2024 | Active |
| Kyle Kennard | LB | — | — | 2025 | Active |
| Ladd McConkey | WR | — | — | 2024 | Active |
| Marcus Maye | FS | — | — | 2017 | Active |
| Marcus Williams | FS | — | — | 2017 | Active |
| Marlowe Wax | LB | — | — | 2025 | Active |
| Mekhi Becton | G | — | — | 2020 | Active |
| Najee Harris | RB | — | — | 2021 | Active |
| Naquan Jones | DT | — | — | 2021 | Active |
| Nikko Reed | DB | — | — | 2025 | Active |
| Nyheim Hines | RB | — | — | 2018 | Active |
| Odafe Oweh | LB | — | — | 2021 | Active |
| Omarion Hampton | RB | — | — | 2025 | Active |
| Oronde Gadsden II | TE | — | — | 2025 | Active |
| Otito Ogbonnia | DT | — | — | 2022 | Active |
| Quentin Johnston | WR | — | — | 2023 | Active |
| R.J. Mickens | SAF | — | — | 2025 | Active |
| Rick Lovato | LS | — | — | 2015 | Active |
| Scott Matlock | DT | — | — | 2023 | Active |
| Tarheeb Still | CB | — | — | 2024 | Active |
| Teair Tart | DT | — | — | 2020 | Active |
| Tony Jefferson | S | — | — | 2013 | Active |
| Trayveon Williams | RB | — | — | 2019 | Active |
| Tre Harris | WR | — | — | 2025 | Active |
| Trevor Penning | OT | — | — | 2022 | Active |
| Trey Lance | QB | — | — | 2021 | Active |
| Trey Pipkins | OT | — | — | 2019 | Active |
| Troy Dye | LB | — | — | 2020 | Active |
| Tucker Fisk | TE | — | — | 2023 | Active |
| Tuli Tuipulotu | LB | — | — | 2023 | Active |
| Tyler Conklin | TE | — | — | 2018 | Active |
| Will Dissly | TE | — | — | 2018 | Active |
| Zion Johnson | G | — | — | 2022 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |