12–5 · #1 in NFC West · Super Bowl LVI ChampionChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| A'Shawn Robinson | DT | — | — | 2016 | Active |
| Aaron Donald | DL | — | — | 2014 | Active |
| Alaric Jackson | OT | — | — | 2021 | Active |
| Andrew Whitworth | OT | — | — | 2006 | Active |
| Antoine Brooks Jr. | SAF | — | — | 2020 | Active |
| Austin Corbett | G | — | — | 2018 | Active |
| Ben Skowronek | WR | — | — | 2021 | Active |
| Bobby Brown III | DT | — | — | 2021 | Active |
| Bobby Evans | G | — | — | 2019 | Active |
| Brandon Powell | WR | — | — | 2018 | Active |
| Brian Allen | C | — | — | 2018 | Active |
| Brycen Hopkins | TE | — | — | 2020 | Active |
| Buddy Howell | RB | — | — | 2018 | Active |
| Cam Akers | RB | — | — | 2020 | Active |
| Chris Garrett | LB | — | — | 2021 | Active |
| Christian Rozeboom | LB | — | — | 2021 | Active |
| Coleman Shelton | C | — | — | 2019 | Active |
| Cooper Kupp | WR | — | — | 2017 | Active |
| Darious Williams | CB | — | — | 2018 | Active |
| Darrell Henderson | RB | — | — | 2019 | Active |
| David Edwards | OT | — | — | 2019 | Active |
| David Long | DB | — | — | 2019 | Active |
| DeSean Jackson | WR | — | — | 2008 | Active |
| Donte' Deayon | CB | — | — | 2017 | Active |
| Ernest Jones | LB | — | — | 2021 | Active |
| Grant Haley | DB | — | — | 2018 | Active |
| Greg Gaines | DT | — | — | 2019 | Active |
| J.J. Koski | WR | — | — | 2021 | Active |
| J.R. Reed | SAF | — | — | 2020 | Active |
| Jacob Harris | WR | — | — | 2021 | Active |
| Jake Funk | RB | — | — | 2021 | Active |
| Jake Gervase | LB | — | — | 2019 | Active |
| Jalen Ramsey | CB | — | — | 2016 | Active |
| Jamir Jones | LB | — | — | 2021 | Active |
| Joe Noteboom | OT | — | — | 2018 | Active |
| John Wolford | QB | — | — | 2020 | Active |
| Johnny Hekker | P | — | — | 2012 | Active |
| Johnny Mundt | TE | — | — | 2017 | Active |
| Jonah Williams | DE | — | — | 2021 | Active |
| Jordan Fuller | SAF | — | — | 2020 | Active |
| JuJu Hughes | S | — | — | 2020 | Active |
| Justin Hollins | LB | — | — | 2019 | Active |
| Justin Lawler | LB | — | — | 2018 | Active |
| Kareem Orr | DB | — | — | 2019 | Active |
| Kendall Blanton | TE | — | — | 2019 | Active |
| Kenny Young | ILB | — | — | 2018 | Active |
| Landen Akers | WR | — | — | 2021 | Active |
| Leonard Floyd | DE | — | — | 2016 | Active |
| Marquise Copeland | DT | — | — | 2020 | Active |
| Matt Gay | K | — | — | 2019 | Active |
| Matthew Orzech | LS | — | — | 2019 | Active |
| Matthew Stafford | QB | — | — | 2009 | Active |
| Mekhi Sargent | RB | — | — | 2021 | Active |
| Micah Kiser | LB | — | — | 2018 | Active |
| Michael Hoecht | LB | — | — | 2021 | Active |
| Nick Scott | SAF | — | — | 2019 | Active |
| Odell Beckham Jr. | WR | — | — | 2014 | Active |
| Ogbo Okoronkwo | LB | — | — | 2019 | Active |
| Rob Havenstein | OT | — | — | 2015 | Active |
| Robert Rochell | CB | — | — | 2021 | Active |
| Robert Woods | WR | — | — | 2013 | Active |
| Sebastian Joseph-Day | DT | — | — | 2019 | Active |
| Sony Michel | RB | — | — | 2018 | Active |
| Taylor Rapp | SAF | — | — | 2019 | Active |
| Terrell Burgess | SAF | — | — | 2020 | Active |
| Terrell Lewis | LB | — | — | 2020 | Active |
| Travin Howard | LB | — | — | 2019 | Active |
| Troy Reeder | LB | — | — | 2019 | Active |
| Tutu Atwell | WR | — | — | 2021 | Active |
| Tyler Hall | CB | — | — | 2020 | Active |
| Tyler Higbee | TE | — | — | 2016 | Active |
| Van Jefferson | WR | — | — | 2020 | Active |
| Von Miller | OLB | — | — | 2011 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |