4–13 · #4 in NFC EastChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Aaron Robinson | CB | — | — | 2021 | Active |
| Adoree' Jackson | CB | — | — | 2017 | Active |
| Alex Bachman | WR | — | — | 2020 | Active |
| Andrew Thomas | OT | — | — | 2020 | Active |
| Austin Johnson | NT | — | — | 2016 | Active |
| Azeez Ojulari | LB | — | — | 2021 | Active |
| Ben Bredeson | G | — | — | 2020 | Active |
| Benardrick McKinney | ILB | — | — | 2015 | Active |
| Billy Price | C | — | — | 2018 | Active |
| Blake Martinez | ILB | — | — | 2016 | Active |
| C.J. Board | WR | — | — | 2019 | Active |
| Cameron Brown | LB | — | — | 2020 | Active |
| Carter Coughlin | LB | — | — | 2020 | Active |
| Casey Kreiter | LS | — | — | 2016 | Active |
| Chris Myarick | TE | — | — | 2020 | Active |
| Collin Johnson | WR | — | — | 2020 | Active |
| Cullen Gillaspia | RB | — | — | 2019 | Active |
| Daniel Jones | QB | — | — | 2019 | Active |
| Danny Shelton | DT | — | — | 2015 | Active |
| Dante Pettis | WR | — | — | 2018 | Active |
| Darius Slayton | WR | — | — | 2019 | Active |
| Darnay Holmes | CB | — | — | 2020 | Active |
| Darqueze Dennard | DB | — | — | 2014 | Active |
| David Moa | DT | — | — | 2021 | Active |
| David Sills | WR | — | — | 2021 | Active |
| Derrick Kelly | OT | — | — | 2020 | Active |
| Devontae Booker | RB | — | — | 2016 | Active |
| Dexter Lawrence | DT | — | — | 2019 | Active |
| Elerson G. Smith | LB | — | — | 2021 | Active |
| Elijhaa Penny | FB | — | — | 2017 | Active |
| Evan Engram | TE | — | — | 2017 | Active |
| Gary Brightwell | RB | — | — | 2021 | Active |
| Graham Gano | K | — | — | 2009 | Active |
| J.R. Reed | SAF | — | — | 2020 | Active |
| Jabrill Peppers | FS | — | — | 2017 | Active |
| Jake Fromm | QB | — | — | 2021 | Active |
| James Bradberry | CB | — | — | 2016 | Active |
| Jarren Williams | CB | — | — | 2020 | Active |
| Jaylon Smith | MLB | — | — | 2017 | Active |
| John Ross | WR | — | — | 2017 | Active |
| Julian Love | SAF | — | — | 2019 | Active |
| Justin Hilliard | LB | — | — | 2021 | Active |
| Kadarius Toney | WR | — | — | 2021 | Active |
| Kaden Smith | TE | — | — | 2019 | Active |
| Keion Crossen | DB | — | — | 2018 | Active |
| Kenny Golladay | WR | — | — | 2017 | Active |
| Korey Cunningham | OT | — | — | 2018 | Active |
| Kyle Rudolph | TE | — | — | 2011 | Active |
| Leonard Williams | DE | — | — | 2015 | Active |
| Logan Ryan | CB | — | — | 2013 | Active |
| Lorenzo Carter | LB | — | — | 2018 | Active |
| Matt Peart | OT | — | — | 2020 | Active |
| Matt Skura | C | — | — | 2017 | Active |
| Mike Glennon | QB | — | — | 2013 | Active |
| Nate Ebner | DB | — | — | 2012 | Active |
| Nate Solder | OT | — | — | 2011 | Active |
| Nick Gates | G | — | — | 2019 | Active |
| Oshane Ximines | LB | — | — | 2019 | Active |
| Pharoh Cooper | WR | — | — | 2016 | Active |
| Quincy Roche | LB | — | — | 2021 | Active |
| Raymond Johnson III | DE | — | — | 2021 | Active |
| Reggie Ragland | ILB | — | — | 2017 | Active |
| Riley Dixon | P | — | — | 2016 | Active |
| Rodarius Williams | CB | — | — | 2021 | Active |
| Sam Beal | DB | — | — | 2019 | Active |
| Saquon Barkley | RB | — | — | 2018 | Active |
| Shane Lemieux | G | — | — | 2020 | Active |
| Sterling Shepard | WR | — | — | 2016 | Active |
| Steven Parker | DB | — | — | 2019 | Active |
| Tae Crowder | LB | — | — | 2020 | Active |
| Trent Harris | LB | — | — | 2019 | Active |
| Wes Martin | G | — | — | 2019 | Active |
| Will Hernandez | G | — | — | 2018 | Active |
| Woodrow Hamilton | DT | — | — | 2016 | Active |
| Xavier McKinney | SAF | — | — | 2020 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |