9–8 · #2 in NFC East · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alex Singleton | LB | — | — | 2019 | Active |
| Andre Chachere | DB | — | — | 2021 | Active |
| Andre Dillard | OT | — | — | 2019 | Active |
| Anthony Harris | DB | — | — | 2015 | Active |
| Arryn Siposs | P | — | — | 2021 | Active |
| Avonte Maddox | FS | — | — | 2018 | Active |
| Boston Scott | RB | — | — | 2018 | Active |
| Brandon Brooks | G | — | — | 2012 | Active |
| Brandon Graham | DE | — | — | 2010 | Active |
| Brett Toth | G | — | — | 2020 | Active |
| Cameron Malveaux | DE | — | — | 2017 | Active |
| Casey Tucker | OT | — | — | 2021 | Active |
| Christian Elliss | LB | — | — | 2021 | Active |
| Dallas Goedert | TE | — | — | 2018 | Active |
| Darius Slay | CB | — | — | 2013 | Active |
| Davion Taylor | LB | — | — | 2020 | Active |
| Derek Barnett | DE | — | — | 2017 | Active |
| DeVonta Smith | WR | — | — | 2021 | Active |
| Elijah Riley | DB | — | — | 2020 | Active |
| Eric Wilson | LB | — | — | 2017 | Active |
| Fletcher Cox | DT | — | — | 2012 | Active |
| Gardner Minshew | QB | — | — | 2019 | Active |
| Genard Avery | DE | — | — | 2018 | Active |
| Greg Ward | WR | — | — | 2019 | Active |
| Hassan Ridgeway | DT | — | — | 2016 | Active |
| Isaac Seumalo | G | — | — | 2016 | Active |
| J.J. Arcega-Whiteside | WR | — | — | 2019 | Active |
| Jack Anderson | G | — | — | 2021 | Active |
| Jack Driscoll | OT | — | — | 2020 | Active |
| Jack Stoll | TE | — | — | 2021 | Active |
| JaCoby Stevens | LB | — | — | 2021 | Active |
| Jake Elliott | K | — | — | 2017 | Active |
| Jalen Hurts | QB | — | — | 2020 | Active |
| Jalen Reagor | WR | — | — | 2020 | Active |
| Jared Mayden | SAF | — | — | 2020 | Active |
| Jason Huntley | RB | — | — | 2020 | Active |
| Jason Kelce | C | — | — | 2011 | Active |
| Javon Hargrave | NT | — | — | 2016 | Active |
| John Hightower | WR | — | — | 2020 | Active |
| Jordan Howard | RB | — | — | 2016 | Active |
| Jordan Mailata | OT | — | — | 2020 | Active |
| Josh Sweat | LB | — | — | 2018 | Active |
| Josiah Scott | CB | — | — | 2020 | Active |
| K'Von Wallace | SAF | — | — | 2020 | Active |
| Kary Vincent Jr. | CB | — | — | 2021 | Active |
| Kayode Awosika | G | — | — | 2021 | Active |
| Kenny Gainwell | RB | — | — | 2021 | Active |
| Landon Dickerson | G | — | — | 2021 | Active |
| Lane Johnson | OT | — | — | 2013 | Active |
| Le'Raven Clark | OT | — | — | 2016 | Active |
| Mac McCain III | CB | — | — | 2021 | Active |
| Marcus Epps | SAF | — | — | 2019 | Active |
| Marlon Tuipulotu | DT | — | — | 2021 | Active |
| Marvin Wilson | DT | — | — | 2021 | Active |
| Miles Sanders | RB | — | — | 2019 | Active |
| Milton Williams | DT | — | — | 2021 | Active |
| Nate Herbig | G | — | — | 2019 | Active |
| Noah Togiai | TE | — | — | 2020 | Active |
| Patrick Johnson | DE | — | — | 2021 | Active |
| Quez Watkins | WR | — | — | 2020 | Active |
| Raequan Williams | DT | — | — | 2020 | Active |
| Richard Rodgers | TE | — | — | 2014 | Active |
| Rick Lovato | LS | — | — | 2015 | Active |
| Rodney McLeod Jr. | FS | — | — | 2012 | Active |
| Ryan Kerrigan | DE | — | — | 2011 | Active |
| Shaun Bradley | LB | — | — | 2020 | Active |
| Steven Nelson | CB | — | — | 2015 | Active |
| Sua Opeta | G | — | — | 2020 | Active |
| T.J. Edwards | LB | — | — | 2019 | Active |
| Tarron Jackson | LB | — | — | 2021 | Active |
| Tay Gowan | CB | — | — | 2021 | Active |
| Tyree Jackson | TE | — | — | 2021 | Active |
| Zach Ertz | TE | — | — | 2013 | Active |
| Zech McPhearson | CB | — | — | 2021 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |