9–8 · #3 in AFC NorthChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Ahkello Witherspoon | CB | — | — | 2017 | Active |
| Alex Highsmith | LB | — | — | 2020 | Active |
| Anthony McFarland | RB | — | — | 2020 | Active |
| Arthur Maulet | CB | — | — | 2017 | Active |
| Benny Snell | RB | — | — | 2019 | Active |
| Cameron Heyward | DE | — | — | 2011 | Active |
| Cameron Sutton | CB | — | — | 2017 | Active |
| Carlos Davis | DT | — | — | 2020 | Active |
| Chase Claypool | WR | — | — | 2020 | Active |
| Chris Boswell | K | — | — | 2015 | Active |
| Chris Wormley | NT | — | — | 2017 | Active |
| Christian Kuntz | LS | — | — | 2021 | Active |
| Chukwuma Okorafor | OT | — | — | 2018 | Active |
| Cody White | WR | — | — | 2021 | Active |
| Connor Heyward | FB | — | — | 2022 | Active |
| Damontae Kazee | S | — | — | 2017 | Active |
| Dan Moore Jr. | OT | — | — | 2021 | Active |
| Delontae Scott | DE | — | — | 2021 | Active |
| DeMarvin Leal | DE | — | — | 2022 | Active |
| Derek Watt | FB | — | — | 2016 | Active |
| Devin Bush | LB | — | — | 2019 | Active |
| Diontae Johnson | WR | — | — | 2019 | Active |
| Elijah Riley | DB | — | — | 2020 | Active |
| George Pickens | WR | — | — | 2022 | Active |
| Gunner Olszewski | WR | — | — | 2019 | Active |
| Isaiahh Loudermilk | DE | — | — | 2021 | Active |
| J.C. Hassenauer | C | — | — | 2020 | Active |
| James Daniels | G | — | — | 2018 | Active |
| James Pierre | CB | — | — | 2020 | Active |
| Jamir Jones | LB | — | — | 2021 | Active |
| Jaylen Warren | RB | — | — | 2022 | Active |
| Jesse Davis | G | — | — | 2017 | Active |
| Josh Jackson | CB | — | — | 2018 | Active |
| Kenny Pickett | QB | — | — | 2022 | Active |
| Kevin Dotson | G | — | — | 2020 | Active |
| Larry Ogunjobi | DT | — | — | 2017 | Active |
| Levi Wallace | DB | — | — | 2018 | Active |
| Malik Reed | LB | — | — | 2019 | Active |
| Marcus Allen | LB | — | — | 2018 | Active |
| Mark Robinson | LB | — | — | 2022 | Active |
| Mason Cole | C | — | — | 2018 | Active |
| Matthew Wright | K | — | — | 2020 | Active |
| Miles Boykin | WR | — | — | 2019 | Active |
| Miles Killebrew | SAF | — | — | 2016 | Active |
| Minkah Fitzpatrick | FS | — | — | 2018 | Active |
| Mitchell Trubisky | QB | — | — | 2017 | Active |
| Montravius Adams | DT | — | — | 2017 | Active |
| Myles Jack | MLB | — | — | 2016 | Active |
| Najee Harris | RB | — | — | 2021 | Active |
| Nick Sciba | K | — | — | 2022 | Active |
| Pat Freiermuth | TE | — | — | 2021 | Active |
| Pressley Harvin III | P | — | — | 2021 | Active |
| Quincy Wilson | CB | — | — | 2017 | Active |
| Renell Wren | DT | — | — | 2019 | Active |
| Robert Spillane | LB | — | — | 2018 | Active |
| Ryan Anderson | LB | — | — | 2017 | Active |
| Steven Sims | WR | — | — | 2019 | Active |
| T.J. Watt | OLB | — | — | 2017 | Active |
| Terrell Edmunds | S | — | — | 2018 | Active |
| Tre Norwood | CB | — | — | 2021 | Active |
| Trent Scott | OT | — | — | 2018 | Active |
| Tyson Alualu | DE | — | — | 2010 | Active |
| Zach Gentry | TE | — | — | 2019 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |