2–14 · #4 in NFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Aaron Burbridge | WR | — | — | 2016 | Active |
| Aaron Lynch | OLB | — | — | 2014 | Active |
| Ahmad Brooks | OLB | — | — | 2006 | Active |
| Alex Balducci | G | — | — | 2016 | Active |
| Andrew Gardner | G | — | — | 2012 | Active |
| Andrew Tiller | G | — | — | 2014 | Active |
| Anthony Davis | OT | — | — | 2010 | Active |
| Antoine Bethea | FS | — | — | 2006 | Active |
| Arik Armstead | DE | — | — | 2015 | Active |
| Blaine Gabbert | QB | — | — | 2011 | Active |
| Blake Bell | TE | — | — | 2015 | Active |
| Bradley Pinion | P | — | — | 2015 | Active |
| Carl Bradford | LB | — | — | 2016 | Active |
| Carlos Hyde | RB | — | — | 2014 | Active |
| Chris Davis | CB | — | — | 2014 | Active |
| Chris Harper | WR | — | — | 2015 | Active |
| Chris Jones | DT | — | — | 2013 | Active |
| Colin Kaepernick | QB | — | — | 2011 | Active |
| Daniel Kilgore | C | — | — | 2012 | Active |
| DeAndre Smelter | WR | — | — | 2016 | Active |
| DeForest Buckner | DT | — | — | 2016 | Active |
| Dontae Johnson | DB | — | — | 2014 | Active |
| DuJuan Harris | RB | — | — | 2011 | Active |
| Eli Harold | LB | — | — | 2015 | Active |
| Eric Reid | S | — | — | 2013 | Active |
| Garrett Celek | TE | — | — | 2012 | Active |
| Gerald Hodges | LB | — | — | 2013 | Active |
| Glenn Dorsey | NT | — | — | 2008 | Active |
| JaCorey Shepherd | CB | — | — | 2016 | Active |
| Jaquiski Tartt | S | — | — | 2015 | Active |
| Je'Ron Hamm | TE | — | — | 2016 | Active |
| Jeremy Kerley | WR | — | — | 2011 | Active |
| Jim Dray | TE | — | — | 2010 | Active |
| Jimmie Ward | SAF | — | — | 2014 | Active |
| Joe Staley | OT | — | — | 2007 | Active |
| John Theus | OT | — | — | 2016 | Active |
| Joshua Garnett | G | — | — | 2016 | Active |
| Keith Reaser | CB | — | — | 2015 | Active |
| Keshawn Martin | WR | — | — | 2012 | Active |
| Kyle Nelson | LS | — | — | 2013 | Active |
| Marcus Ball | DB | — | — | 2014 | Active |
| Marcus Cromartie | DB | — | — | 2014 | Active |
| Marcus Martin | C | — | — | 2014 | Active |
| Michael Wilhoite | OLB | — | — | 2012 | Active |
| Mike Davis | RB | — | — | 2015 | Active |
| Mike Purcell | NT | — | — | 2014 | Active |
| NaVorro Bowman | MLB | — | — | 2010 | Active |
| Nick Bellore | LB | — | — | 2011 | Active |
| Phil Dawson | K | — | — | — | Active |
| Prince Charles Iworah | CB | — | — | 2016 | Active |
| Quinton Dial | DT | — | — | 2013 | Active |
| Quinton Patton | WR | — | — | 2013 | Active |
| Raheem Mostert | RB | — | — | 2015 | Active |
| Rashard Robinson | CB | — | — | 2016 | Active |
| Ray-Ray Armstrong | LB | — | — | 2013 | Active |
| Rod Streater | WR | — | — | 2012 | Active |
| Ronald Blair | DE | — | — | 2016 | Active |
| Shaun Draughn | RB | — | — | 2012 | Active |
| Shayne Skov | LB | — | — | 2015 | Active |
| Tank Carradine | DE | — | — | 2014 | Active |
| Taylor Hart | DE | — | — | 2015 | Active |
| Tony Jerod-Eddie | DE | — | — | 2013 | Active |
| Torrey Smith | WR | — | — | 2011 | Active |
| Tramaine Brock | DB | — | — | 2010 | Active |
| Trent Brown | OT | — | — | 2015 | Active |
| Vance McDonald | TE | — | — | 2013 | Active |
| Vinnie Sunseri | DB | — | — | 2014 | Active |
| Wynton McManis | LB | — | — | 2016 | Active |
| Zane Beadles | G | — | — | 2010 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |