6–10 · #4 in NFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Aaron Lynch | OLB | — | — | 2014 | Active |
| Adrian Colbert | FS | — | — | 2017 | Active |
| Ahkello Witherspoon | CB | — | — | 2017 | Active |
| Aldrick Robinson | WR | — | — | 2012 | Active |
| Antone Exum | S | — | — | 2014 | Active |
| Arik Armstead | DE | — | — | 2015 | Active |
| Asa Jackson | DB | — | — | 2012 | Active |
| Bradley Pinion | P | — | — | 2015 | Active |
| Brandon Fusco | G | — | — | 2011 | Active |
| Brian Hoyer | QB | — | — | 2009 | Active |
| Brock Coyle | LB | — | — | 2014 | Active |
| C.J. Beathard | QB | — | — | 2017 | Active |
| Carlos Hyde | RB | — | — | 2014 | Active |
| Cassius Marsh | LB | — | — | 2014 | Active |
| Cole Hikutini | TE | — | — | 2017 | Active |
| D.J. Jones | DT | — | — | 2017 | Active |
| Daniel Kilgore | C | — | — | 2012 | Active |
| Darrell Williams | OT | — | — | 2017 | Active |
| Datone Jones | DE | — | — | 2013 | Active |
| DeForest Buckner | DT | — | — | 2016 | Active |
| Dekoda Watson | LB | — | — | 2010 | Active |
| Dexter McCoil | DB | — | — | 2016 | Active |
| Dontae Johnson | DB | — | — | 2014 | Active |
| Earl Mitchell | DT | — | — | 2010 | Active |
| Eli Harold | LB | — | — | 2015 | Active |
| Elijah Lee | OLB | — | — | 2017 | Active |
| Elvis Dumervil | DE | — | — | 2006 | Active |
| Eric Reid | S | — | — | 2013 | Active |
| Erik Magnuson | C | — | — | 2017 | Active |
| Garrett Celek | TE | — | — | 2012 | Active |
| Garry Gilliam | OT | — | — | 2014 | Active |
| George Kittle | TE | — | — | 2017 | Active |
| Greg Mabin | CB | — | — | 2017 | Active |
| Jaquiski Tartt | S | — | — | 2015 | Active |
| Jeremy McNichols | RB | — | — | 2017 | Active |
| Jimmie Ward | SAF | — | — | 2014 | Active |
| Jimmy Garoppolo | QB | — | — | 2014 | Active |
| Joe Staley | OT | — | — | 2007 | Active |
| K'Waun Williams | DB | — | — | 2014 | Active |
| Keith Reaser | CB | — | — | 2015 | Active |
| Kendrick Bourne | WR | — | — | 2017 | Active |
| Kyle Juszczyk | FB | — | — | 2013 | Active |
| Kyle Nelson | LS | — | — | 2013 | Active |
| Laken Tomlinson | G | — | — | 2015 | Active |
| Leger Douzable | DE | — | — | 2009 | Active |
| Leon Hall | DB | — | — | 2007 | Active |
| Logan Paulsen | TE | — | — | 2010 | Active |
| Lorenzo Jerome | DB | — | — | 2017 | Active |
| Louis Murphy | WR | — | — | 2009 | Active |
| Mark Nzeocha | OLB | — | — | 2015 | Active |
| Marquise Goodwin | WR | — | — | 2013 | Active |
| Matt Breida | RB | — | — | 2017 | Active |
| NaVorro Bowman | MLB | — | — | 2010 | Active |
| Pierre Garcon | WR | — | — | 2008 | Active |
| Pita Taumoepenu | LB | — | — | 2017 | Active |
| Raheem Mostert | RB | — | — | 2015 | Active |
| Rashard Robinson | CB | — | — | 2016 | Active |
| Ray-Ray Armstrong | LB | — | — | 2013 | Active |
| Reuben Foster | OLB | — | — | 2017 | Active |
| Robbie Gould | K | — | — | 2005 | Active |
| Ronald Blair | DE | — | — | 2016 | Active |
| Sheldon Day | DT | — | — | 2016 | Active |
| Solomon Thomas | DE | — | — | 2017 | Active |
| Tank Carradine | DE | — | — | 2014 | Active |
| Tim Barnes | C | — | — | 2013 | Active |
| Tony McDaniel | DT | — | — | 2006 | Active |
| Trent Brown | OT | — | — | 2015 | Active |
| Trent Taylor | WR | — | — | 2017 | Active |
| Tyvis Powell | DB | — | — | 2016 | Active |
| Victor Bolden | WR | — | — | 2017 | Active |
| Xavier Cooper | DE | — | — | 2015 | Active |
| Zane Beadles | G | — | — | 2010 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |