4–12 · #3 in NFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Adrian Colbert | FS | — | — | 2017 | Active |
| Ahkello Witherspoon | CB | — | — | 2017 | Active |
| Alfred Morris | RB | — | — | 2012 | Active |
| Antone Exum | S | — | — | 2014 | Active |
| Arik Armstead | DE | — | — | 2015 | Active |
| Bradley Pinion | P | — | — | 2015 | Active |
| Brock Coyle | LB | — | — | 2014 | Active |
| C.J. Beathard | QB | — | — | 2017 | Active |
| Cassius Marsh | LB | — | — | 2014 | Active |
| Cole Wick | TE | — | — | 2016 | Active |
| Colin Holba | LS | — | — | 2017 | Active |
| D.J. Jones | DT | — | — | 2017 | Active |
| D.J. Reed | CB | — | — | 2018 | Active |
| Dante Pettis | WR | — | — | 2018 | Active |
| DeForest Buckner | DT | — | — | 2016 | Active |
| Dekoda Watson | LB | — | — | 2010 | Active |
| Earl Mitchell | DT | — | — | 2010 | Active |
| Elijah Lee | OLB | — | — | 2017 | Active |
| Emmanuel Moseley | DB | — | — | 2018 | Active |
| Erik Magnuson | C | — | — | 2017 | Active |
| Fred Warner | MLB | — | — | 2018 | Active |
| Garrett Celek | TE | — | — | 2012 | Active |
| Garry Gilliam | OT | — | — | 2014 | Active |
| George Kittle | TE | — | — | 2017 | Active |
| Godwin Igwebuike | RB | — | — | 2018 | Active |
| Greg Mabin | CB | — | — | 2017 | Active |
| James Onwualu | LB | — | — | 2017 | Active |
| Jaquiski Tartt | S | — | — | 2015 | Active |
| Jeff Wilson | RB | — | — | 2018 | Active |
| Jimmie Ward | SAF | — | — | 2014 | Active |
| Jimmy Garoppolo | QB | — | — | 2014 | Active |
| Joe Staley | OT | — | — | 2007 | Active |
| Joshua Garnett | G | — | — | 2016 | Active |
| Jullian Taylor | DT | — | — | 2018 | Active |
| K'Waun Williams | DB | — | — | 2014 | Active |
| Kendrick Bourne | WR | — | — | 2017 | Active |
| Kyle Juszczyk | FB | — | — | 2013 | Active |
| Kyle Nelson | LS | — | — | 2013 | Active |
| Laken Tomlinson | G | — | — | 2015 | Active |
| Malcolm Smith | MLB | — | — | 2011 | Active |
| Marcell Harris | DB | — | — | 2018 | Active |
| Mark Nzeocha | OLB | — | — | 2015 | Active |
| Marquise Goodwin | WR | — | — | 2013 | Active |
| Matt Breida | RB | — | — | 2017 | Active |
| Matt Dayes | RB | — | — | 2017 | Active |
| Max McCaffrey | WR | — | — | 2017 | Active |
| Mike McGlinchey | OT | — | — | 2018 | Active |
| Mike Person | G | — | — | 2013 | Active |
| Nick Mullens | QB | — | — | 2018 | Active |
| Pierre Garcon | WR | — | — | 2008 | Active |
| Pita Taumoepenu | LB | — | — | 2017 | Active |
| Raheem Mostert | RB | — | — | 2015 | Active |
| Reuben Foster | OLB | — | — | 2017 | Active |
| Richard Sherman | CB | — | — | 2011 | Active |
| Richie James | WR | — | — | 2018 | Active |
| Robbie Gould | K | — | — | 2005 | Active |
| Ronald Blair | DE | — | — | 2016 | Active |
| Ross Dwelley | TE | — | — | 2018 | Active |
| Ryan Delaire | DE | — | — | 2015 | Active |
| Sheldon Day | DT | — | — | 2016 | Active |
| Solomon Thomas | DE | — | — | 2017 | Active |
| Steven Dunbar | WR | — | — | 2018 | Active |
| Tarvarius Moore | DB | — | — | 2018 | Active |
| Terence Garvin | LB | — | — | 2013 | Active |
| Trent Taylor | WR | — | — | 2017 | Active |
| Tyvis Powell | DB | — | — | 2016 | Active |
| Victor Bolden | WR | — | — | 2017 | Active |
| Weston Richburg | C | — | — | 2014 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |