13–3 · #1 in NFC West · Lost Super Bowl LIVChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Ahkello Witherspoon | CB | — | — | 2017 | Active |
| Anthony Zettel | DE | — | — | 2016 | Active |
| Antone Exum | S | — | — | 2014 | Active |
| Arik Armstead | DE | — | — | 2015 | Active |
| Azeez Al-Shaair | LB | — | — | 2019 | Active |
| Ben Garland | C | — | — | 2014 | Active |
| Chase McLaughlin | K | — | — | 2019 | Active |
| Colin Holba | LS | — | — | 2017 | Active |
| D.J. Jones | DT | — | — | 2017 | Active |
| D.J. Reed | CB | — | — | 2018 | Active |
| Damontre Moore | DE | — | — | 2013 | Active |
| Daniel Brunskill | OT | — | — | 2019 | Active |
| Dante Pettis | WR | — | — | 2018 | Active |
| Dee Ford | DE | — | — | 2014 | Active |
| Deebo Samuel Sr. | WR | — | — | 2019 | Active |
| DeForest Buckner | DT | — | — | 2016 | Active |
| Dontae Johnson | DB | — | — | 2014 | Active |
| Dre Greenlaw | LB | — | — | 2019 | Active |
| Elijah Lee | OLB | — | — | 2017 | Active |
| Emmanuel Moseley | DB | — | — | 2018 | Active |
| Emmanuel Sanders | WR | — | — | 2010 | Active |
| Fred Warner | MLB | — | — | 2018 | Active |
| Garrett Celek | TE | — | — | 2012 | Active |
| Garrison Sanborn | LS | — | — | 2009 | Active |
| George Kittle | TE | — | — | 2017 | Active |
| Jaquiski Tartt | S | — | — | 2015 | Active |
| Jason Verrett | DB | — | — | 2014 | Active |
| Jeff Wilson | RB | — | — | 2018 | Active |
| Jeremiah Valoaga | DE | — | — | 2017 | Active |
| Jimmie Ward | SAF | — | — | 2014 | Active |
| Jimmy Garoppolo | QB | — | — | 2014 | Active |
| Joe Staley | OT | — | — | 2007 | Active |
| Jon Condo | LS | — | — | 2007 | Active |
| Jordan Matthews | TE | — | — | 2014 | Active |
| Jullian Taylor | DT | — | — | 2018 | Active |
| Justin Skule | OT | — | — | 2019 | Active |
| K'Waun Williams | DB | — | — | 2014 | Active |
| Kendrick Bourne | WR | — | — | 2017 | Active |
| Kentavius Street | DE | — | — | 2019 | Active |
| Kevin Givens | DT | — | — | 2019 | Active |
| Kwon Alexander | MLB | — | — | 2015 | Active |
| Kyle Juszczyk | FB | — | — | 2013 | Active |
| Kyle Nelson | LS | — | — | 2013 | Active |
| Laken Tomlinson | G | — | — | 2015 | Active |
| Levine Toilolo | TE | — | — | 2013 | Active |
| Marcell Harris | DB | — | — | 2018 | Active |
| Mark Nzeocha | OLB | — | — | 2015 | Active |
| Marquise Goodwin | WR | — | — | 2013 | Active |
| Matt Breida | RB | — | — | 2017 | Active |
| Mike McGlinchey | OT | — | — | 2018 | Active |
| Mike Person | G | — | — | 2013 | Active |
| Mitch Wishnowsky | P | — | — | 2019 | Active |
| Nick Bosa | DE | — | — | 2019 | Active |
| Nick Mullens | QB | — | — | 2018 | Active |
| Raheem Mostert | RB | — | — | 2015 | Active |
| Richard Sherman | CB | — | — | 2011 | Active |
| Richie James | WR | — | — | 2018 | Active |
| Robbie Gould | K | — | — | 2005 | Active |
| Ronald Blair | DE | — | — | 2016 | Active |
| Ross Dwelley | TE | — | — | 2018 | Active |
| Sam Young | OT | — | — | 2012 | Active |
| Sheldon Day | DT | — | — | 2016 | Active |
| Solomon Thomas | DE | — | — | 2017 | Active |
| Tarvarius Moore | DB | — | — | 2018 | Active |
| Tevin Coleman | RB | — | — | 2015 | Active |
| Weston Richburg | C | — | — | 2014 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |