13–4 · #1 in NFC West · Lost NFC ChampionshipChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Aaron Banks | G | — | — | 2021 | Active |
| Akeem Spence | DT | — | — | 2013 | Active |
| Ambry Thomas | CB | — | — | 2021 | Active |
| Arik Armstead | DE | — | — | 2015 | Active |
| Azeez Al-Shaair | LB | — | — | 2019 | Active |
| Blake Hance | G | — | — | 2021 | Active |
| Brandon Aiyuk | WR | — | — | 2020 | Active |
| Brock Purdy | QB | — | — | 2022 | Active |
| Charles Omenihu | DE | — | — | 2019 | Active |
| Charlie Woerner | TE | — | — | 2020 | Active |
| Charvarius Ward | CB | — | — | 2018 | Active |
| Christian McCaffrey | RB | — | — | 2017 | Active |
| Colton McKivitz | OT | — | — | 2020 | Active |
| Curtis Robinson | LB | — | — | 2021 | Active |
| Daniel Brunskill | OT | — | — | 2019 | Active |
| Danny Gray | WR | — | — | 2022 | Active |
| Deebo Samuel Sr. | WR | — | — | 2019 | Active |
| Demetrius Flannigan-Fowles | LB | — | — | 2020 | Active |
| Deommodore Lenoir | CB | — | — | 2021 | Active |
| Dontae Johnson | DB | — | — | 2014 | Active |
| Drake Jackson | DE | — | — | 2022 | Active |
| Dre Greenlaw | LB | — | — | 2019 | Active |
| Elijah Mitchell | RB | — | — | 2021 | Active |
| Emmanuel Moseley | DB | — | — | 2018 | Active |
| Fred Warner | MLB | — | — | 2018 | Active |
| George Kittle | TE | — | — | 2017 | Active |
| George Odum | DB | — | — | 2018 | Active |
| Hassan Ridgeway | DT | — | — | 2016 | Active |
| Jake Brendel | C | — | — | 2016 | Active |
| Janoris Jenkins | CB | — | — | 2012 | Active |
| Jauan Jennings | WR | — | — | 2021 | Active |
| Javon Kinlaw | DT | — | — | 2020 | Active |
| Jaylon Moore | OT | — | — | 2021 | Active |
| Jeff Wilson | RB | — | — | 2018 | Active |
| Jimmie Ward | SAF | — | — | 2014 | Active |
| Jimmy Garoppolo | QB | — | — | 2014 | Active |
| Jordan Mason | RB | — | — | 2022 | Active |
| Jordan Willis | DE | — | — | 2017 | Active |
| Josh Johnson | QB | — | — | 2009 | Active |
| Kemoko Turay | DE | — | — | 2018 | Active |
| Kerry Hyder | DE | — | — | 2015 | Active |
| Kevin Givens | DT | — | — | 2019 | Active |
| Kyle Juszczyk | FB | — | — | 2013 | Active |
| Malik Turner | WR | — | — | 2018 | Active |
| Marlon Mack | RB | — | — | 2017 | Active |
| Michael Dwumfour | DT | — | — | 2021 | Active |
| Mike McGlinchey | OT | — | — | 2018 | Active |
| Mitch Wishnowsky | P | — | — | 2019 | Active |
| Nick Bosa | DE | — | — | 2019 | Active |
| Nick Zakelj | OT | — | — | 2022 | Active |
| Oren Burks | ILB | — | — | 2018 | Active |
| Ray-Ray McCloud | WR | — | — | 2018 | Active |
| Robbie Gould | K | — | — | 2005 | Active |
| Ross Dwelley | TE | — | — | 2018 | Active |
| Samson Ebukam | DE | — | — | 2017 | Active |
| Samuel Womack | CB | — | — | 2022 | Active |
| Spencer Burford | G | — | — | 2022 | Active |
| T.Y. McGill | DT | — | — | 2015 | Active |
| Talanoa Hufanga | SAF | — | — | 2021 | Active |
| Tarvarius Moore | DB | — | — | 2018 | Active |
| Tashaun Gipson | FS | — | — | 2012 | Active |
| Tay Martin | WR | — | — | 2022 | Active |
| Taybor Pepper | LS | — | — | 2017 | Active |
| Tevin Coleman | RB | — | — | 2015 | Active |
| Trent Williams | OT | — | — | 2010 | Active |
| Trey Lance | QB | — | — | 2021 | Active |
| Tyler Kroft | TE | — | — | 2015 | Active |
| Tyrion Davis-Price | RB | — | — | 2022 | Active |
| Willie Snead | WR | — | — | 2015 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |