12–5 · #3 in NFC West · Lost Divisional RoundChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Adrian Martinez | QB | — | — | 2025 | Active |
| Alfred Collins | DT | — | — | 2025 | Active |
| Austen Pleasants | OL | — | — | 2021 | Active |
| Ben Bartch | OT | — | — | 2020 | Active |
| Brayden Willis | TE | — | — | 2023 | Active |
| Brian Robinson | RB | — | — | 2022 | Active |
| Brock Purdy | QB | — | — | 2022 | Active |
| Bryce Huff | DE | — | — | 2020 | Active |
| Chase Lucas | CB | — | — | 2022 | Active |
| Christian McCaffrey | RB | — | — | 2017 | Active |
| CJ West | DT | — | — | 2025 | Active |
| Clelin Ferrell | DE | — | — | 2019 | Active |
| Colton McKivitz | OT | — | — | 2020 | Active |
| Connor Colby | G | — | — | 2025 | Active |
| Curtis Robinson | LB | — | — | 2021 | Active |
| Darrell Luter Jr. | CB | — | — | 2023 | Active |
| Dee Winters | LB | — | — | 2023 | Active |
| Demarcus Robinson | WR | — | — | 2016 | Active |
| Deommodore Lenoir | CB | — | — | 2021 | Active |
| Dominick Puni | OT | — | — | 2024 | Active |
| Drew Moss | G | — | — | 2025 | Active |
| Eddy Pineiro | K | — | — | 2019 | Active |
| Eli Apple | CB | — | — | 2016 | Active |
| Eric Kendricks | MLB | — | — | 2015 | Active |
| Fred Warner | MLB | — | — | 2018 | Active |
| Garret Wallow | LB | — | — | 2021 | Active |
| George Kittle | TE | — | — | 2017 | Active |
| Isaac Guerendo | RB | — | — | 2024 | Active |
| Jake Brendel | C | — | — | 2016 | Active |
| Jake Moody | K | — | — | 2023 | Active |
| Jake Tonges | TE | — | — | 2022 | Active |
| Jalen Graham | LB | — | — | 2023 | Active |
| Jason Pinnock | SAF | — | — | 2021 | Active |
| Jauan Jennings | WR | — | — | 2021 | Active |
| Ji'Ayir Brown | SAF | — | — | 2023 | Active |
| Jon Weeks | LS | — | — | 2010 | Active |
| Jordan Elliott | DT | — | — | 2020 | Active |
| Jordan James | RB | — | — | 2025 | Active |
| Jordan Jefferson | DT | — | — | 2024 | Active |
| Jordan Watkins | WR | — | — | 2025 | Active |
| Kalia Davis | DT | — | — | 2023 | Active |
| Keion White | DE | — | — | 2023 | Active |
| Kendrick Bourne | WR | — | — | 2017 | Active |
| Kevin Givens | DT | — | — | 2019 | Active |
| Kyle Juszczyk | FB | — | — | 2013 | Active |
| Luke Farrell | TE | — | — | 2021 | Active |
| Luke Gifford | LB | — | — | 2019 | Active |
| Mac Jones | QB | — | — | 2021 | Active |
| Malik Mustapha | SAF | — | — | 2024 | Active |
| Malik Turner | WR | — | — | 2018 | Active |
| Marques Sigle | SAF | — | — | 2025 | Active |
| Marquez Valdes-Scantling | WR | — | — | 2018 | Active |
| Matt Gay | K | — | — | 2019 | Active |
| Matt Hennessy | C | — | — | 2020 | Active |
| Mykel Williams | DE | — | — | 2025 | Active |
| Nick Bosa | DE | — | — | 2019 | Active |
| Nick Martin | LB | — | — | 2025 | Active |
| Nick Zakelj | OT | — | — | 2022 | Active |
| Renardo Green | CB | — | — | 2024 | Active |
| Ricky Pearsall | WR | — | — | 2024 | Active |
| Robert Beal Jr. | DE | — | — | 2023 | Active |
| Russell Gage | WR | — | — | 2018 | Active |
| Sam Okuayinonu | DT | — | — | 2022 | Active |
| Siran Neal | DB | — | — | 2018 | Active |
| Skyy Moore | WR | — | — | 2022 | Active |
| Spencer Burford | G | — | — | 2022 | Active |
| Tatum Bethune | LB | — | — | 2024 | Active |
| Thomas Morstead | P | — | — | 2009 | Active |
| Trent Williams | OT | — | — | 2010 | Active |
| Trevis Gipson | LB | — | — | 2020 | Active |
| Upton Stout | CB | — | — | 2025 | Active |
| Yetur Gross-Matos | DE | — | — | 2020 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |