4–0 · #1 in NFC WestChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Ashtyn Davis | DB | #24 | California | 2020 | Active |
| Brandin Cooks | WR | #84 | Oregon State | 2014 | Active |
| Brayden Willis | TE | #9 | Oklahoma | 2023 | Active |
| Brock Purdy | QB | #13 | Iowa State | 2022 | Active |
| Carver Willis | OL | #74 | Washington | 2026 | Active |
| Christian McCaffrey | RB | #23 | Stanford | 2017 | Active |
| Colton McKivitz | OL | #68 | West Virginia | 2020 | Active |
| Connor Colby | OL | #75 | Iowa | 2025 | Active |
| Corliss Waitman | P | #15 | South Alabama | 2021 | Active |
| Deebo Samuel Sr. | WR | #19 | South Carolina | 2019 | Active |
| Deommodore Lenoir | DB | #2 | Oregon | 2021 | Active |
| Dominick Puni | OL | #77 | Kansas | 2024 | Active |
| Dre Greenlaw | LB | #57 | Arkansas | 2019 | Active |
| Eddy Pineiro | K | #18 | Florida | 2019 | Active |
| Enrique Cruz Jr. | OL | #69 | Kansas | — | Active |
| Ephesians Prysock | DB | #28 | Washington | — | Active |
| Fred Warner | LB | #54 | BYU | 2018 | Active |
| Garret Wallow | LB | #49 | TCU | 2021 | Active |
| George Kittle | TE | #85 | Iowa | 2017 | Active |
| Gracen Halton | DL | #93 | Oklahoma | 2026 | Active |
| Jack Jones | DB | #25 | Arizona State | 2022 | Active |
| Jacob Cowing | WR | #4 | Arizona | 2024 | Active |
| Jaden Dugger | LB | #53 | Louisiana | 2026 | Active |
| Jake Brendel | OL | #64 | UCLA | 2016 | Active |
| James Thompson Jr. | DL | #96 | Illinois | 2026 | Active |
| Jarrett Patterson | OL | #58 | Notre Dame | 2023 | Active |
| Ji'Ayir Brown | DB | #27 | Penn State | 2023 | Active |
| Jon Weeks | LS | #46 | Baylor | 2010 | Active |
| Jordan James | RB | #29 | Oregon | 2025 | Active |
| Jordan Watkins | WR | #17 | Mississippi | 2025 | Active |
| Kaelon Black | RB | #26 | Indiana | 2026 | Active |
| Keion White | DL | #56 | Georgia Tech | 2023 | Active |
| Khalid Kareem | DL | #47 | Notre Dame | 2020 | Active |
| Kurtis Rourke | QB | #14 | Indiana | — | Active |
| Kyle Juszczyk | RB | #44 | Harvard | 2013 | Active |
| Luke Farrell | TE | #89 | Ohio State | 2021 | Active |
| Luke Gifford | LB | #51 | Nebraska | 2019 | Active |
| Mac Jones | QB | #10 | Alabama | 2021 | Active |
| Malik Mustapha | DB | #6 | Wake Forest | 2024 | Active |
| Marques Sigle | DB | #36 | Kansas State | 2025 | Active |
| Mike Evans | WR | #5 | Texas A&M | 2014 | Active |
| Naquan Jones | DL | #50 | Michigan State | 2021 | Active |
| Nick Bosa | DL | #97 | Ohio State | 2019 | Active |
| Ogbo Okoronkwo | DL | #59 | Oklahoma | 2019 | Active |
| Osa Odighizuwa | DL | #92 | UCLA | 2021 | Active |
| Renardo Green | DB | #0 | Florida State | 2024 | Active |
| Romello Height | DL | #94 | Texas Tech | 2026 | Active |
| Sebastian Valdez | DL | #55 | Washington | 2026 | Active |
| Siran Neal | DB | #33 | Jacksonville State | 2018 | Active |
| Tatum Bethune | LB | #48 | Florida State | 2024 | Active |
| Trent Williams | OL | #71 | Oklahoma | 2010 | Active |
| Upton Stout | DB | #20 | Western Kentucky | 2025 | Active |
| Vederian Lowe | OL | #76 | Illinois | 2022 | Active |
| Alfred Collins | DL | #95 | Texas | 2025 | Reserve |
| Andrew Farmer II | LB | #50 | Lane College | 2023 | Reserve |
| Austen Pleasants | OL | #62 | Ohio | 2021 | Reserve |
| Brandon Codrington | DB | #17 | North Carolina Central | 2024 | Practice squad |
| Brett Toth | OL | #78 | Army | 2020 | Reserve |
| C.J. West | DL | #99 | Indiana | 2025 | Reserve |
| Christian Kirk | WR | #3 | Texas A&M | 2018 | Reserve |
| Dante Pettis | WR | #87 | Washington | 2018 | Practice squad |
| Darrick Forrest | DB | #29 | Cincinnati | 2021 | Reserve |
| De'Zhaun Stribling | WR | #7 | Mississippi | 2026 | Reserve |
| Demarcus Robinson | WR | #11 | Florida | 2016 | Reserve |
| Drake Nugent | OL | #66 | Michigan | — | Practice squad |
| Foster Sarell | OL | #70 | Stanford | 2022 | Practice squad |
| Isaac Alarcon | OL | #67 | — | — | Practice squad |
| Isaac Guerendo | RB | #31 | Louisville | 2024 | Reserve |
| Jack Stoll | TE | #89 | Nebraska | 2021 | Practice squad |
| Jake Tonges | TE | #88 | California | 2022 | Reserve |
| Jalen Graham | LB | #41 | Purdue | 2023 | Practice squad |
| Jalen Stroman | DB | #38 | Notre Dame | — | Practice squad |
| Kevin Givens | DL | #90 | Penn State | 2019 | Practice squad |
| Khalil Dinkins | TE | #43 | Penn State | — | Practice squad |
| Malik Turner | WR | #86 | Illinois | 2018 | Practice squad |
| Matthew Judon | LB | #43 | Grand Valley | 2016 | Practice squad |
| McKinnley Jackson | DL | #91 | Texas A&M | 2024 | Practice squad |
| Mikail Kamara | DL | #59 | Indiana | — | Reserve |
| Mykel Williams | DL | #98 | Georgia | 2025 | Reserve |
| Nate Hobbs | DB | #22 | Illinois | 2021 | Reserve |
| Nick Martin | LB | #45 | Oklahoma State | 2025 | Reserve |
| Nick Zakelj | OL | #63 | Fordham | 2022 | Reserve |
| Ricky Pearsall | WR | #1 | Florida | 2024 | Reserve |
| Sam Okuayinonu | DL | #91 | Maryland | 2022 | Reserve |
| Sincere McCormick | RB | #35 | Texas-San Antonio | 2024 | Practice squad |
| Viliami Fehoko Jr. | DL | #63 | San Jose State | 2026 | Practice squad |
| Wesley Grimes | WR | #81 | N.C. State | — | Practice squad |
| Will Pauling | WR | #84 | Notre Dame | — | Practice squad |
| Xavier Smith | WR | #19 | Florida A&M | 2024 | Practice squad |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Buffalo Bills | 3–1 | .750 | +20 |
 New England Patriots | 2–2 | .500 | -12 |
 New York Jets | 1–3 | .250 | -8 |
 Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Baltimore Ravens | 3–1 | .750 | +20 |
| Cleveland Browns |
| 3–1 |
| .750 |
| -14 |
 Cincinnati Bengals | 2–2 | .500 | +12 |
|---|
 Pittsburgh Steelers | 2–2 | .500 | -10 |
|---|
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Jacksonville Jaguars | 3–1 | .750 | +51 |
 Indianapolis Colts | 2–2 | .500 | -2 |
 Houston Texans | 0–4 | .000 | -25 |
 Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Kansas City Chiefs | 4–0 | 1.000 | +41 |
 Las Vegas Raiders | 3–1 | .750 | +31 |
 Denver Broncos | 2–2 | .500 | -20 |
 Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 New York Giants | 3–1 | .750 | +3 |
 Dallas Cowboys | 2–2 | .500 | +10 |
 Philadelphia Eagles | 2–2 | .500 | -18 |
 Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Minnesota Vikings | 4–0 | 1.000 | +35 |
 Chicago Bears | 3–1 | .750 | +47 |
 Detroit Lions | 2–2 | .500 | -8 |
 Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Carolina Panthers | 2–2 | .500 | +12 |
 Atlanta Falcons | 2–2 | .500 | +4 |
 New Orleans Saints | 1–3 | .250 | -23 |
 Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| San Francisco 49ers | 4–0 | 1.000 | +58 |
 Seattle Seahawks | 3–1 | .750 | +32 |
 Los Angeles Rams | 2–2 | .500 | +2 |
 Arizona Cardinals | 1–3 | .250 | -30 |
