12–4 · #1 in NFC West · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alex Boone | OT | — | — | 2011 | Active |
| Alex Collins | RB | — | — | 2016 | Active |
| Alton Robinson | LB | — | — | 2020 | Active |
| Anthony Rush | NT | — | — | 2019 | Active |
| B.J. Finney | G | — | — | 2016 | Active |
| Ben Burr-Kirven | LB | — | — | 2019 | Active |
| Benson Mayowa | OLB | — | — | 2013 | Active |
| Bo Scarbrough | RB | — | — | 2019 | Active |
| Bobby Wagner | MLB | — | — | 2012 | Active |
| Brandon Shell | OT | — | — | 2016 | Active |
| Bruce Irvin | LB | — | — | 2012 | Active |
| Bryan Mone | NT | — | — | 2019 | Active |
| Carlos Dunlap | DE | — | — | 2010 | Active |
| Carlos Hyde | RB | — | — | 2014 | Active |
| Cedric Ogbuehi | OT | — | — | 2015 | Active |
| Chad Wheeler | OT | — | — | 2017 | Active |
| Chris Carson | RB | — | — | 2017 | Active |
| Cody Barton | LB | — | — | 2019 | Active |
| Colby Parkinson | TE | — | — | 2020 | Active |
| D.J. Reed | CB | — | — | 2018 | Active |
| D'Andre Walker | OLB | — | — | 2020 | Active |
| Damarious Randall | S | — | — | 2015 | Active |
| Damien Lewis | G | — | — | 2020 | Active |
| Damon Harrison | DT | — | — | 2013 | Active |
| Damontre Moore | DE | — | — | 2013 | Active |
| David Moore | WR | — | — | 2017 | Active |
| DeeJay Dallas | RB | — | — | 2020 | Active |
| DK Metcalf | WR | — | — | 2019 | Active |
| Duane Brown | OT | — | — | 2008 | Active |
| Ethan Pocic | C | — | — | 2017 | Active |
| Freddie Swain | WR | — | — | 2020 | Active |
| Geno Smith | QB | — | — | 2013 | Active |
| Greg Olsen | TE | — | — | 2007 | Active |
| Jacob Hollister | TE | — | — | 2017 | Active |
| Jamal Adams | LB | — | — | 2017 | Active |
| Jamarco Jones | OT | — | — | 2019 | Active |
| Jarran Reed | DT | — | — | 2016 | Active |
| Jason Myers | K | — | — | 2015 | Active |
| Jayson Stanley | DB | — | — | 2020 | Active |
| Jonathan Bullard | DE | — | — | 2016 | Active |
| Jordan Simmons | G | — | — | 2018 | Active |
| Jordyn Brooks | LB | — | — | 2020 | Active |
| K.J. Wright | OLB | — | — | 2011 | Active |
| Kyle Fuller | G | — | — | 2017 | Active |
| L.J. Collier | DE | — | — | 2019 | Active |
| Lano Hill | SAF | — | — | 2017 | Active |
| Linden Stephens | CB | — | — | 2019 | Active |
| Luke Willson | TE | — | — | 2013 | Active |
| Marquise Blair | DB | — | — | 2019 | Active |
| Michael Dickson | P | — | — | 2018 | Active |
| Mike Iupati | G | — | — | 2010 | Active |
| Neiko Thorpe | CB | — | — | 2012 | Active |
| Nick Bellore | LB | — | — | 2011 | Active |
| Penny Hart | WR | — | — | 2020 | Active |
| Phil Haynes | G | — | — | 2020 | Active |
| Poona Ford | DT | — | — | 2018 | Active |
| Quandre Diggs | S | — | — | 2015 | Active |
| Quinton Dunbar | CB | — | — | 2015 | Active |
| Rashaad Penny | RB | — | — | 2018 | Active |
| Rasheem Green | DE | — | — | 2018 | Active |
| Ray-Ray Armstrong | LB | — | — | 2013 | Active |
| Russell Wilson | QB | — | — | 2012 | Active |
| Ryan Neal | DB | — | — | 2018 | Active |
| Shaquem Griffin | OLB | — | — | 2018 | Active |
| Shaquill Griffin | CB | — | — | 2017 | Active |
| Stephen Sullivan | TE | — | — | 2020 | Active |
| Travis Homer | RB | — | — | 2019 | Active |
| Tre Flowers | CB | — | — | 2018 | Active |
| Tyler Lockett | WR | — | — | 2015 | Active |
| Tyler Ott | LS | — | — | 2015 | Active |
| Ugo Amadi | CB | — | — | 2019 | Active |
| Will Dissly | TE | — | — | 2018 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |