7–9 · #1 in NFC East · Lost Wild CardChoose season
| Player | Pos | # | College | Debut | Status |
|---|---|---|---|---|---|
| Alex Smith | QB | — | — | 2005 | Active |
| Antonio Gandy-Golden | WR | — | — | 2020 | Active |
| Antonio Gibson | RB | — | — | 2020 | Active |
| Brandon Scherff | G | — | — | 2015 | Active |
| Cam Sims | WR | — | — | 2018 | Active |
| Casey Toohill | DE | — | — | 2020 | Active |
| Chase Roullier | C | — | — | 2017 | Active |
| Chase Young | DE | — | — | 2020 | Active |
| Cole Holcomb | LB | — | — | 2019 | Active |
| Cole Luke | CB | — | — | 2019 | Active |
| Cornelius Lucas | OT | — | — | 2014 | Active |
| Danny Johnson | DB | — | — | 2018 | Active |
| Daron Payne | NT | — | — | 2018 | Active |
| David Sharpe | OT | — | — | 2017 | Active |
| David Steinmetz | OT | — | — | 2020 | Active |
| Deshazor Everett | DB | — | — | 2015 | Active |
| Devaroe Lawrence | DT | — | — | 2018 | Active |
| Dontrelle Inman | WR | — | — | 2014 | Active |
| Dustin Hopkins | K | — | — | 2015 | Active |
| Dwayne Haskins | QB | — | — | 2019 | Active |
| Fabian Moreau | CB | — | — | 2017 | Active |
| Geron Christian | OT | — | — | 2018 | Active |
| Greg Stroman | CB | — | — | 2018 | Active |
| Isaiah Wright | WR | — | — | 2020 | Active |
| J.D. McKissic | RB | — | — | 2016 | Active |
| James Smith-Williams | DE | — | — | 2020 | Active |
| Jared Norris | LB | — | — | 2016 | Active |
| Javon Leake | RB | — | — | 2020 | Active |
| Jeff Badet | WR | — | — | 2020 | Active |
| Jeremy Reaves | DB | — | — | 2018 | Active |
| Jeremy Sprinkle | TE | — | — | 2017 | Active |
| Jimmy Moreland | CB | — | — | 2019 | Active |
| Jon Bostic | ILB | — | — | 2013 | Active |
| Jonathan Allen | DE | — | — | 2017 | Active |
| Jordan Kunaszyk | ILB | — | — | 2019 | Active |
| Joshua Garnett | G | — | — | 2016 | Active |
| Kam Curl | SAF | — | — | 2020 | Active |
| Keith Ismael | C | — | — | 2020 | Active |
| Kendall Fuller | CB | — | — | 2016 | Active |
| Kevin Pierre-Louis | LB | — | — | 2014 | Active |
| Khaleke Hudson | LB | — | — | 2020 | Active |
| Kyle Allen | QB | — | — | 2018 | Active |
| Landon Collins | LB | — | — | 2015 | Active |
| Logan Thomas | TE | — | — | 2014 | Active |
| Marcus Baugh | TE | — | — | 2020 | Active |
| Matthew Ioannidis | DT | — | — | 2016 | Active |
| Mike Warren | RB | — | — | 2020 | Active |
| Montez Sweat | DE | — | — | 2019 | Active |
| Morgan Moses | OT | — | — | 2014 | Active |
| Mychal Kendricks | LB | — | — | 2012 | Active |
| Nate Orchard | DE | — | — | 2015 | Active |
| Nick Sundberg | LS | — | — | 2010 | Active |
| Peyton Barber | RB | — | — | 2016 | Active |
| Robert Foster | WR | — | — | 2018 | Active |
| Ronald Darby | CB | — | — | 2015 | Active |
| Ryan Anderson | LB | — | — | 2017 | Active |
| Ryan Kerrigan | DE | — | — | 2011 | Active |
| Saahdiq Charles | OT | — | — | 2020 | Active |
| Shaun Dion Hamilton | LB | — | — | 2018 | Active |
| Steven Sims | WR | — | — | 2019 | Active |
| Taylor Heinicke | QB | — | — | 2017 | Active |
| Temarrick Hemingway | TE | — | — | 2016 | Active |
| Terry McLaurin | WR | — | — | 2019 | Active |
| Thomas Davis | OLB | — | — | 2005 | Active |
| Tim Settle | DT | — | — | 2018 | Active |
| Tony Brown | WR | — | — | 2020 | Active |
| Tress Way | P | — | — | 2014 | Active |
| Troy Apke | DB | — | — | 2018 | Active |
| Wes Martin | G | — | — | 2019 | Active |
| Wes Schweitzer | G | — | — | 2017 | Active |
| 3–1 |
| .750 |
| -14 |
| 2–2 | .500 | +12 |
| 2–2 | .500 | -10 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +51 | |
| 2–2 | .500 | -2 | |
| 0–4 | .000 | -25 | |
| 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +41 | |
| 3–1 | .750 | +31 | |
| 2–2 | .500 | -20 | |
| 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 3–1 | .750 | +3 | |
| 2–2 | .500 | +10 | |
| 2–2 | .500 | -18 | |
| 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +35 | |
| 3–1 | .750 | +47 | |
| 2–2 | .500 | -8 | |
| 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 2–2 | .500 | +12 | |
| 2–2 | .500 | +4 | |
| 1–3 | .250 | -23 | |
| 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| 4–0 | 1.000 | +58 | |
| 3–1 | .750 | +32 | |
| 2–2 | .500 | +2 | |
| 1–3 | .250 | -30 |