49ers at Lions: 41–33
49ersSF0–0
Week 1 September 12, 2021
4133
Final
LionsDET0–0
1st quarter 15:00Kickoff
SF0DET0Turnover on Downs (Q1 15:00)6 plays, 39 yards, 2:59
SF0DET0SF0DET0SF0DET0| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Buffalo Bills | 3–1 | .750 | +20 |
 New England Patriots | 2–2 | .500 | -12 |
 New York Jets | 1–3 | .250 | -8 |
 Miami Dolphins | 0–4 | .000 | -55 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Baltimore Ravens | 3–1 | .750 | +20 |
| Cleveland Browns |
| 3–1 |
| .750 |
| -14 |
 Cincinnati Bengals | 2–2 | .500 | +12 |
|---|
 Pittsburgh Steelers | 2–2 | .500 | -10 |
|---|
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Jacksonville Jaguars | 3–1 | .750 | +51 |
 Indianapolis Colts | 2–2 | .500 | -2 |
 Houston Texans | 0–4 | .000 | -25 |
 Tennessee Titans | 0–4 | .000 | -28 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Kansas City Chiefs | 4–0 | 1.000 | +41 |
 Las Vegas Raiders | 3–1 | .750 | +31 |
 Denver Broncos | 2–2 | .500 | -20 |
 Los Angeles Chargers | 0–4 | .000 | -39 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 New York Giants | 3–1 | .750 | +3 |
 Dallas Cowboys | 2–2 | .500 | +10 |
 Philadelphia Eagles | 2–2 | .500 | -18 |
 Washington Commanders | 1–3 | .250 | -34 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Minnesota Vikings | 4–0 | 1.000 | +35 |
 Chicago Bears | 3–1 | .750 | +47 |
| Detroit Lions | 2–2 | .500 | -8 |
 Green Bay Packers | 2–2 | .500 | -32 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
 Carolina Panthers | 2–2 | .500 | +12 |
 Atlanta Falcons | 2–2 | .500 | +4 |
 New Orleans Saints | 1–3 | .250 | -23 |
 Tampa Bay Buccaneers | 0–4 | .000 | -20 |
| Team | W–L–T | PCT | DIFF |
|---|---|---|---|
| San Francisco 49ers | 4–0 | 1.000 | +58 |
 Seattle Seahawks | 3–1 | .750 | +32 |
 Los Angeles Rams | 2–2 | .500 | +2 |
 Arizona Cardinals | 1–3 | .250 | -30 |
